Reduction of Initial Corrosion Rate and Improvement of Cell Adhesion Through Surface Modification of Biodegradable Mg Alloy

한형섭                                    /Hyung-Seop Han; 이선희; 김원주; 전호정                                         /Jeon; Hojeong; 석현광; 안재평                                         /Jaepyoung Ahn; 김유찬                                         /Yuchan Kim

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자료유형: 학술저널

저자정보: 한형섭 /Hyung-Seop Han 이선희 김원주 전호정 /Jeon Hojeong 석현광 안재평 /Jaepyoung Ahn 김유찬 /Yuchan Kim

저널정보: 대한금속·재료학회 Metals and Materials International Metals and Materials International Vol.21 No.1

발행연도: 2015.1

수록면: 194 - 201 (8page)

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In this study, the surface modification of biodegradable pure Magnesium and Mg-5wt%Ca-1wt%Zn alloywas performed through immersion in HBSS, inorganic salt solution and cell media to reduce initial hydrogenevolution and improve cell adhesion. The formation of different CaP-like coatings from immersion ofpure Mg and Mg alloy were observed using Cryo FIB analysis and their performances were measuredthrough cell adhesion, quantification of released Mg ions, and cell cytotoxicity assays. The coating layersdisplayed significant reduction of initial corrosion rate, and cell adhesion for both pure Mg and Mg alloyappeared to be influenced by the amino acids and proteins in the cell media. In general, Mg alloy showeda denser coating layer with higher Ca contents, resulting in greater reduction of initial corrosion rate andimproved cell adhesion, when compared to pure Mg. This is due to saturation of Ca around the corrosionsite that provided much favorable environmental condition to produce denser calcium phosphate coatingmixture. The result from this study suggests that the surface modification of biodegradable Mg alloy byimmersion in alkaline solutions can be utilized to obtain ideal biodegradable orthopedic implant materialwith reduced initial hydrogen evolution rate and improved cell adhesion.

#biomaterials #metals #alloys #surface modification #corrosion #focused ion beam

참고문헌 (28)

참고문헌 신청

이민호 / 2007 / Evaluation of in vitro and in vivo tests for Surface-Modified Titanium by H2SO4 and H2O2 Treatment / Metals and Materials International 13(2):109~115

P. Tengvall / 1992 / Clin. Mater 9:115

E. Giordani / 2004 / Int. J. Fatigue 26:1129

S. Yen / 2001 / Biomaterials 22:125

B. Denkena / 2007 / CIRP. Ann-Manuf. Techn 56:113

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