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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 95 - 113 (19page)
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Patients with diabetes mellitus (DM) have accelerated atherosclerosis with an increased risk for atherothrombotic cardiovascular complications. A state of high platelet reactivity and activation, hypercoagulability (prothrombotic state) and a subdued response to standard antiplatelet agents may explain high rate of adverse cardiovascular events in patients with DM. Several antithrombotic treatment strategies have been developed to control the prothrombotic state in patients with DM: dose modification of commonly used agents; use of potent agents; and addition of a third antithrombotic drug (triple therapy) to commonly prescribed dual antiplatelet therapy of aspirin and a P2Y12 inhibitor. The present review aims to provide an overview of the current knowledge on platelet abnormalities in patients with DM, focusing on the challenges and perspectives of antiplatelet treatment strategies in this population.
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등록된 정보가 없습니다.
참고문헌 (65)
참고문헌 신청
World Health Organization / Global status report on noncommunicable diseases
Emerging Risk Factors Collaboration / 2010 / Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies / Lancet 375:2215~2222
Haffner SM / 1998 / Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction / N Engl J Med 339:229~234
Morel O / 2010 / Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosis / Atherosclerosis 212:367~376
Patti G / 2014 / Antiplatelet therapy in patients with diabetes mellitus and acute coronary syndrome / Circ J 78:33~41
Emerging Risk Factors Collaboration / 2010 / Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies / Lancet 375:2215~2222
Haffner SM / 1998 / Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction / N Engl J Med 339:229~234
Morel O / 2010 / Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosis / Atherosclerosis 212:367~376
Patti G / 2014 / Antiplatelet therapy in patients with diabetes mellitus and acute coronary syndrome / Circ J 78:33~41
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