지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.68 No.1
- 발행연도
- 2015.1
- 수록면
- 43 - 49 (7page)
이용수
초록· 키워드
오류제보하기
Background: We investigated the effects of the combined administration of nefopam, a N-methyl-D-aspartate receptorantagonist and low dose remifentanil, on early postoperative pain and analgesic requirement.
Methods: Fifty patients scheduled to undergo mastoidectomy and tympanoplasty were randomized to be given eithernefopam 40 mg mixed with normal saline 100 ml (Group N) or an equal amount of normal saline (Group C) before anesthesiainduction. Anesthesia was maintained with 5–6 vol% desflurane and remifentanil 0.05–0.15 μg/kg/min duringthe surgery. Postoperative pain was controlled by titration of ketorolac in the postanesthesia care unit (PACU) and ward.
We evaluated the intraoperative remifentanil dose, recovery profiles, ketorolac demand in the PACU and ward, numericrating scale (NRS) for pain at time intervals of every 10 min for 1 h in the PACU, 6, 12, 18 and 24 h in a ward, as well asthe time to first analgesic requirement in the PACU and ward.
Results: Ketorolac demand and NRS in the PACU were significantly lower in Group N than Group C (P = 0.002, P = 0.005,respectively). The time to first analgesic requirement in the PACU in Group N were significantly longer than Group C (P= 0.046). There were no significant differences in intraoperative remifentanil dose, ketorolac demand, NRS, and the timeto first analgesic requirement in the ward between the groups.
Conclusions: Nefopam administration combined with low dose remifentanil infusion reduces pain and analgesic consumptionduring the immediate postoperative period in patients undergoing middle ear surgery under desflurane anesthesia.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Mandel JE. / 2014 / Considerations for the use of short-acting opioids in general anesthesia / J Clin Anesth 26(1 Suppl):1~7
Thompson JP / 1996 / Remifentanilan--opioid for the 21st century / Br J Anaesth 76:341~343
Angst MS / 2003 / Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal / Pain 106:49~57
Chu LF / 2008 / Opioid-induced hyperalgesia in humans : molecular mechanisms and clinical considerations / Clin J Pain 24:479~496
이철 / 2013 / Antihyperalgesic effects of dexmedetomidine on high-dose remifentanil-induced hyperalgesia / Korean Journal of Anesthesiology 64(4):301~307
Thompson JP / 1996 / Remifentanilan--opioid for the 21st century / Br J Anaesth 76:341~343
Angst MS / 2003 / Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal / Pain 106:49~57
Chu LF / 2008 / Opioid-induced hyperalgesia in humans : molecular mechanisms and clinical considerations / Clin J Pain 24:479~496
이철 / 2013 / Antihyperalgesic effects of dexmedetomidine on high-dose remifentanil-induced hyperalgesia / Korean Journal of Anesthesiology 64(4):301~307
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