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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.68 No.3
- 발행연도
- 2015.1
- 수록면
- 281 - 286 (6page)
이용수
초록· 키워드
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Background: Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have required caution when used. In this context, several approaches are required to deal with the shortcomings of such a doubleedged drug. Anesthetics are known to protect against ischemic reperfusion injury, and their protective role in ischemic post-conditioning is crucial for reducing ischemia-related injury. The aim of this study was to assess the effect of isoflurane post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. Methods: Cerebral ischemia was modeled in male Sprague-Dawley rats (n = 32) by occluding the right middle cerebral artery for 1 h, followed by intravenous tPA administration. Rats were randomly divided into control and isoflurane posttreatment group, and isoflurane post-treatment group was post-treated by administering 1.5% isoflurane for 1 h from the start of reperfusion. Twenty-four h after reperfusion, neurobehavioral changes were assessed. The extent of cerebral infarction and intracranial hemorrhage were also assessed by quantification of infarction volume and cerebral hemoglobin concentration from brain tissue, respectively. Results: Neurobehavioral testing showed better functional outcomes in the isoflurane post-treatment group than the control group. The extent of cerebral infarction and intracranial hemorrhage were both reduced in isoflurane post-treatment group compared to control group. Conclusions: Isoflurane post-treatment may mitigate infarction volume and intracranial hemorrhage in tPA-exaggerated brain injury. Our findings provide an encouraging novel approach for enhancing clinical outcomes in tPA-exaggerated brain injury.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Feigin VL / 2014 / Global and regional burden of stroke during 1990-2010 : findings from the Global Burden of Disease Study 2010 / Lancet 383:245~254
Eissa A / 2012 / Optimizing the management of acute ischaemic stroke : a review of the utilizaion of intravenous recombinant tissue plasminogen activator(tPA) / J Clin Pharm Ther 37:620~629
Wardlaw JM / 2014 / Thrombolysis for acute ischaemic stroke / Cochrane Database Syst Rev 29:000213
Yepes M / 2009 / Tissue-type plasminogen activator in the ischemic brain : more than a thrombolytic / Trends Neurosci 32:48~55
Zhu H / 2010 / Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke / J Cereb Blood Flow Metab 30:1137~1146
Eissa A / 2012 / Optimizing the management of acute ischaemic stroke : a review of the utilizaion of intravenous recombinant tissue plasminogen activator(tPA) / J Clin Pharm Ther 37:620~629
Wardlaw JM / 2014 / Thrombolysis for acute ischaemic stroke / Cochrane Database Syst Rev 29:000213
Yepes M / 2009 / Tissue-type plasminogen activator in the ischemic brain : more than a thrombolytic / Trends Neurosci 32:48~55
Zhu H / 2010 / Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke / J Cereb Blood Flow Metab 30:1137~1146
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