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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 8 - 16 (9page)
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GIT1, a multifunctional signaling adaptor protein, is implicated in the development of dendritic spines and neuronal synapses. GIT1 forms a signaling complex with PIX, RAC, and PAK proteins that is known to play important roles in brain development. Here we found that Git1-knockout (Git1–/–) mice show a microcephaly-like small brain phenotype, which appears to be caused by reduced neuronal size rather than number. Git1–/– mice also show decreased dendritic spine number without morphological alterations in the hippocampus. Behaviorally, Git1–/– mice show impaired motor coordination and learning and memory. In addition, adult dGit Drosophila mutants show decreased brain size and abnormal morphology of the mushroom body. These results suggest that GIT1 is important for brain development in both rodents and flies.
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참고문헌 (32)
참고문헌 신청
Hoefen RJ / 2006 / The multifunctional GIT family of proteins / J Cell Sci 119:1469~1475
Ko J / 2003 / Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting / J Neurosci 23:1667~1677
Zhang H / 2003 / Synapse formation is regulated by the signaling adaptor GIT1 / J Cell Biol 161:131~142
Zhang H / 2005 / A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC / J Neurosci 25:3379~3388
Kim S / 2003 / The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo / J Biol Chem 278:6291~6300
Ko J / 2003 / Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting / J Neurosci 23:1667~1677
Zhang H / 2003 / Synapse formation is regulated by the signaling adaptor GIT1 / J Cell Biol 161:131~142
Zhang H / 2005 / A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC / J Neurosci 25:3379~3388
Kim S / 2003 / The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo / J Biol Chem 278:6291~6300
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