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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 41 - 54 (14page)
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Ischemic stroke results in the diverse phathophysiologies including blood brain barrier (BBB) disruption, brain edema, neuronal cell death, and synaptic loss in brain. Vitamin C has known as the potent anti-oxidant having multiple functions in various organs, as well as in brain. Dehydroascorbic acid (DHA) as the oxidized form of ascorbic acid (AA) acts as a cellular protector against oxidative stress and easily enters into the brain compared to AA. To determine the role of DHA on edema formation, neuronal cell death, and synaptic dysfunction following cerebral ischemia, we investigated the infarct size of ischemic brain tissue and measured the expression of aquaporin 1 (AQP-1) as the water channel protein. We also examined the expression of claudin 5 for confirming the BBB breakdown, and the expression of bcl 2 associated X protein (Bax), caspase-3, inducible nitric oxide synthase (iNOS) for checking the effect of DHA on the neurotoxicity. Finally, we examined postsynaptic density protein-95 (PSD-95) expression to confirm the effect of DHA on synaptic dysfunction following ischemic stroke. Based on our findings, we propose that DHA might alleviate the pathogenesis of ischemic brain injury by attenuating edema, neuronal loss, and by improving synaptic connection.
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등록된 정보가 없습니다.
참고문헌 (88)
참고문헌 신청
Luo Y / 2014 / Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats / Brain Res 1565:37~47
Nito C / 2008 / Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in bloodbrain barrier disruption after focal cerebral ischemia and reperfusion / J Cereb Blood Flow Metab 28:1686~1696
Diaz-Ruiz A / 2014 / Metallothionein-II inhibits lipid peroxidation and improves functional recovery after transient brain ischemia and reperfusion in rats / Oxid Med Cell Longev 2014:436429
Mahadik SP / 2001 / Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 25:463~493
Zhao J / 2007 / Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury / J Neurosci 27:10240~10248
Nito C / 2008 / Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in bloodbrain barrier disruption after focal cerebral ischemia and reperfusion / J Cereb Blood Flow Metab 28:1686~1696
Diaz-Ruiz A / 2014 / Metallothionein-II inhibits lipid peroxidation and improves functional recovery after transient brain ischemia and reperfusion in rats / Oxid Med Cell Longev 2014:436429
Mahadik SP / 2001 / Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 25:463~493
Zhao J / 2007 / Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury / J Neurosci 27:10240~10248
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