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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 869 - 875 (7page)
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초록· 키워드
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Study Design: A retrospective study. Purpose: To evaluate the immunity-enhancing effect of implantation of a liquid nitrogen-treated tumor. Overview of Literature: We have developed a new technique of implanting a tumor frozen in liquid nitrogen after posterior decompression and stabilization, with the aim of enhancing antitumor immunity in order to prolong the survival period of the patient. In the current study, the immunity-enhancing effect of this new technique has been evaluated. Methods: The subjects were 19 patients in whom we had earlier performed decompression and stabilization between April 2011 and September 2013. The 19 subjects were divided into two groups, namely a frozen autologous tumor tissue implantation group (n=15; “implantation group”), which consisted of patients, who underwent implantation with autologous tumor tissue frozen in liquid nitrogen, and a control group (n=4), which consisted of patients, who did not undergo autologous cancer transplantation. To evaluate the immunity-enhancing effect of the protocol, plasma cytokines (interferon [IFN]-γ and interleukin [IL]-12) were analyzed before surgery and a month after surgery. Results: The mean rate of increase in IFN-γ was significantly higher in the implantation group (p =0.03). Regarding IL-12, no significant difference was observed between the groups, although the implantation group exhibited increased levels of IL-12 (p =0.22). Conclusions: Decompression and stabilization combined with autologous frozen tumor cell implantation can enhance cancer immunity in metastatic spinal tumor patients. It is hypothesized that this procedure might prevent local recurrence and prolong survival period.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Patchell RA / 2005 / Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial / Lancet 366:643~648
Tai LH / 2013 / Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells / Cancer Res 73:97~107
Tomita K / 2001 / Surgical strategy for spinal metastases / Spine (Phila Pa 1976) 26:298~306
Neeman E / 2013 / Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement / Brain Behav Immun 30(Suppl):S32~S40
Tsuchiya H / 2005 / Reconstruction using an autograft containing tumour treated by liquid nitrogen / J Bone Joint Surg Br 87:218~225
Tai LH / 2013 / Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells / Cancer Res 73:97~107
Tomita K / 2001 / Surgical strategy for spinal metastases / Spine (Phila Pa 1976) 26:298~306
Neeman E / 2013 / Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement / Brain Behav Immun 30(Suppl):S32~S40
Tsuchiya H / 2005 / Reconstruction using an autograft containing tumour treated by liquid nitrogen / J Bone Joint Surg Br 87:218~225
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