지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 90 - 99 (10page)
이용수
초록· 키워드
오류제보하기
Objective: A prospective, randomized controlled trial was conducted to evaluate the efficacy of nerve-sparing radicalhysterectomy (NSRH) in preserving bladder function and its oncologic safety in the treatment of cervical cancer.
Methods: From March 2003 to November 2005, 92 patients with cervical cancer stage IA2 to IIA were randomly assigned forsurgical treatment with conventional radical hysterectomy (CRH) or NSRH, and 86 patients finally included in the analysis.
Adequacy of nerve sparing, radicality, bladder function, and oncologic safety were assessed by quantifying the nerve fibers inthe paracervix, measuring the extent of paracervix and harvested lymph nodes (LNs), urodynamic study (UDS) with InternationalProstate Symptom Score (IPSS), and 10-year disease-free survival (DFS), respectively.
Results: There were no differences in clinicopathologic characteristics between two groups. The median number of nerve fiberwas 12 (range, 6 to 21) and 30 (range, 17 to 45) in the NSRH and CRH, respectively (p<0.001). The extent of resected paracervixand number of LNs were not different between the two groups. Volume of residual urine and bladder compliance weresignificantly deteriorated at 12 months after CRH. On the contrary, all parameters of UDS were recovered no later than 3 monthsafter NSRH. Evaluation of the IPSS showed that the frequency of long-term urinary symptom was higher in CRH than in theNSRH group. The median duration before the postvoid residual urine volume became less than 50 mL was 11 days (range, 7 to26 days) in NSRH group and was 18 days (range, 10 to 85 days) in CRH group (p<0.001). No significant difference was observedin the 10-year DFS between two groups.
Conclusion: NSRH appears to be effective in preserving bladder function without sacrificing oncologic safety.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Donato DM / 1999 / Surgical management of stage IB-IIA cervical carcinoma / Semin Surg Oncol 16:232~235
Zullo MA / 2003 / Vesical dysfunctions after radical hysterectomy for cervical cancer: a critical review / Crit Rev Oncol Hematol 48:287~293
Ercoli A / 2003 / Classical and nerve-sparing radical hysterectomy: an evaluation of the risk of injury to the autonomous pelvic nerves / Surg Radiol Anat 25:200~206
Maas CP / 2003 / Nerve sparing radical hysterectomy: latest developments and historical perspective / Crit Rev Oncol Hematol 48:271~279
Landoni F / 2001 / Class II versus class III radical hysterectomy in stage IB-IIA cervical cancer: a prospective randomized study / Gynecol Oncol 80:3~12
Zullo MA / 2003 / Vesical dysfunctions after radical hysterectomy for cervical cancer: a critical review / Crit Rev Oncol Hematol 48:287~293
Ercoli A / 2003 / Classical and nerve-sparing radical hysterectomy: an evaluation of the risk of injury to the autonomous pelvic nerves / Surg Radiol Anat 25:200~206
Maas CP / 2003 / Nerve sparing radical hysterectomy: latest developments and historical perspective / Crit Rev Oncol Hematol 48:271~279
Landoni F / 2001 / Class II versus class III radical hysterectomy in stage IB-IIA cervical cancer: a prospective randomized study / Gynecol Oncol 80:3~12
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