지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background:Excess body fat accumulation contributes to the development of metabolic disorders that can cause adverse health effects. Carnosic acid (CA), a major bioactive component of rosemary (Rosemarinus officinalis), has been suggested to possess anti-adipogenicproperties. The present study was conducted to elucidate the mechanism underlying the anti-adipogenic effects of CA.
Methods:3T3-L1 pre-adipocytes were treated with CA (0.1, 1, and 10 μM) from day 0 to day 8 of differentiation. On day 8, biochemicalmarkers of lipid accumulation and the degree of fatty acid desaturation were measured.
Results:Oil Red O staining results, triglyceride (TG) accumulation, and glycerol 3-phosphate dehydrogenase activity suggested that CAsignificantly inhibited lipid accumulation in 3T3-L1 adipocytes. CA significantly decreased mRNA expression of peroxisome proliferator-activated receptor-γ, sterol regulatory element-binding protein 1, and CCAAT/enhancer binding protein-αin a dose-dependent manner. Moreover, it decreased the ratio of both C16:1/C16:0 and C18:1/C18:0, with reduced expression of stearoyl CoA desaturase 1 mRNAand protein.
Conclusions:These results suggest that CA efficiently suppressed adipogenesis in 3T3-L1 adipocytes and its action, at least in part, isassociated with the downregulation of adipogenesis-related genes and the fatty acid composition of TG accumulated in adipocytes.
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참고문헌 (32)
참고문헌 신청
Otto TC / 2005 / Adipose development: from stem cell to adipocyte / Crit Rev Biochem Mol Biol 40:229~242
Tan CY / 2008 / Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese / Biochem Soc Trans 36:935~940
Virtue S / 2008 / It's not how fat you are, it's what you do with it that counts / PLoS Biol 6:e237
Rosen ED / 2006 / Adipocyte differentiation from the inside out / Nat Rev Mol Cell Biol 7:885~896
Hulver MW / 2005 / Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans / Cell Metab 2:251~261
Tan CY / 2008 / Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese / Biochem Soc Trans 36:935~940
Virtue S / 2008 / It's not how fat you are, it's what you do with it that counts / PLoS Biol 6:e237
Rosen ED / 2006 / Adipocyte differentiation from the inside out / Nat Rev Mol Cell Biol 7:885~896
Hulver MW / 2005 / Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans / Cell Metab 2:251~261
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