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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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This retrospective study was performed to analyze the long-term outcome of topicalcorticosteroid treatment for severe dry eye associated with Sjögren’s syndrome (SS).
Patients who had severe dry eye associated with SS were topically treated with loteprednoletabonate 0.5% (group A, n=66) or fluorometholone 0.1% (group B, n=67) twicedaily and were followed up for 2 years. Visual acuity (VA), intraocular pressure (IOP),Schirmer test, tear film breakup time (BUT), keratoepitheliopathy, and symptomscores were measured at baseline and 6, 12, 18, and 24 months after treatment. VAand IOP were not changed significantly during follow-up in either group. Schirmer testresults, keratoepitheliopathy, and symptom scores at 6, 12, 18, and 24 months (p＜0.05)and tear film BUT at 12, 18, and 24 months (p＜0.05) significantly improved after treatmentcompared with baseline in both groups. No significant differences between thegroups were found in any parameter during follow-up. At 24 months, the number ofpatients with IOP elevation of more than 2 mmHg compared with baseline was 4 ingroup A (6.1%) and 9 in group B (13.4%). The mean IOP in these patients was lowerin group A than in group B (15.00±0.82 mmHg versus 16.50±1.12 mmHg; p=0.04).
Long-term application of low-dose topical corticosteroids is effective for controllingsigns and symptoms of chronic, severe dry eye associated with SS. Loteprednol etabonate0.5% may have a lower risk for IOP elevation than fluorometholone 0.1%.
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