지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 162 - 171 (10page)
이용수
초록· 키워드
오류제보하기
In ischemic heart disease, cardiomyocyte death results from both necrosis and apoptosis, and the area of infarction gradually increases. The induction of therapeutic angiogenesis is a promising therapy for this condition. In the present study, we investigated the actions of SV peptide—a 7-amino-acid sequence with angiogenic properties derived from osteopontin in the extracellular matrix—in a rat model of myocardial ischemia. We examined the angiogenesis activity of SV ex vivo using ring assay and dorsal air sac assay and in ischemic myocardium. We also conducted histological evaluations of left-ventricle remodeling and evaluated left ventricular (LV) function by echocardiography. The SV peptide had strong angiogenic effects both ex vivo and in vivo. In the experimental rats, this peptide stimulated the formation of new blood vessels in ischemic myocardium. Histological evaluation of the left ventricle in the SV-treated group showed a significant decrease in the size of the infarction, rate of myocardial fibrosis, and cardiomyocyte hypertrophy. Moreover, administration of the SV peptide significantly improved LV function. These results indicate that SV peptide induced angiogenesis in ischemic myocardium and improved cardiac function. Thus, it could serve as a potentially useful new therapy for ischemic heart disease.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Aoki M / 2000 / Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets / Gene Ther 7:417~427
Tomita S / 1999 / Autologous transplantation of bone marrow cells improves damaged heart function / Circulation 100(19 Suppl):II247~II256
Yang J / 2005 / Cell sheet engineering : recreating tissues without biodegradable scaffolds / Biomaterials 26:6415~6422
Yoo KJ / 2000 / Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy / Ann Thorac Surg 70:859~865
Jayasankar V / 2003 / Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure / Circulation 108:II230~II236
Tomita S / 1999 / Autologous transplantation of bone marrow cells improves damaged heart function / Circulation 100(19 Suppl):II247~II256
Yang J / 2005 / Cell sheet engineering : recreating tissues without biodegradable scaffolds / Biomaterials 26:6415~6422
Yoo KJ / 2000 / Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy / Ann Thorac Surg 70:859~865
Jayasankar V / 2003 / Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure / Circulation 108:II230~II236
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
스마트 그리드를 위한 샘플 값들의 트래픽 발생 방안
한국인터넷방송통신학회 논문지
2015 .01
-
Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction
조직공학과 재생의학
2018 .01
-
Mesenchymal Stem Cell Transplantation for Ischemic Diseases: Mechanisms and Challenges
조직공학과 재생의학
2021 .01
-
Peptides as multifunctional players in cancer therapy
Experimental and Molecular Medicine
2023 .06
-
The anti-microbial peptide SR-0379 stimulates human endothelial progenitor cell-mediated repair of peripheral artery diseases
BMB Reports
2017 .01
-
The Platform Technology of Peptide-based Cancer Therapy
한국고분자학회 학술대회 연구논문 초록집
2024 .09
-
Immobilization of Angiogenic Peptides in Mesenchymal Stem Cell Membrane for Liver Fibrosis Attenuation via Ex-vivo Cell Surface Engineering
한국고분자학회 학술대회 연구논문 초록집
2024 .09
-
Enhanced Gene Knockdown through Fusion Peptide-mediated siRNA Delivery
한국생물공학회 학술대회
2018 .04
-
Design and Synthesis of Multifunctional Hybrid Peptides against Pathogenic Microbes
한국생물공학회 학술대회
2024 .09
-
Stable and Effective Antimicrobial Peptide Delivery System by Self-entrapping Antimicrobial Peptides in Silica Particles
한국생물공학회 학술대회
2024 .09
-
양손 임피던스법에 의한 SV 측정의 정확도 향상을 위한 연구
전기학회논문지
2015 .08
-
Action Mechanism of a Chimeric Peptide Against Pathogenic Fungal Strains
한국생물공학회 학술대회
2020 .06
-
Polyphenol-Based Oxygen-Releasing Particles for The Treatment Strategy of Ischemic Diseases
한국생물공학회 학술대회
2023 .10
-
Newly Identified Partial Peptide Derived from Human Neutrophil Peptide-1 Promotes Hemostasis
한국생물공학회 학술대회
2019 .10
-
Polymer materials to enhance DNA and peptide functions
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
Sampled Value 시각동기 검증을 위한 측정장치 개발에 관한 연구
대한전기학회 학술대회 논문집
2021 .07
-
Engineered M13 Peptide Carrier Promotes Angiogenic Potential of Patient-Derived Human Cardiac Progenitor Cells and In Vivo Engraftment
조직공학과 재생의학
2020 .01
-
National Designation of Peptides with Potent Antimicrobial Action and Low Cytotoxic effect
한국생물공학회 학술대회
2015 .04
-
Antibacterial Actions of Synthetic Peptides with Repeated Sequence in Drug-resistant Bacteria
한국생물공학회 학술대회
2015 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0