근치적 절제 후 1년 이내 조기 재발하는 대장암

정상훈; 김희철; 김아영; 최평화; 박인자; 유창식; 김진천

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자료유형: 학술저널

저자정보: 정상훈 (영남대학교) 김희철 (울산대학교) 김아영 (울산대학교) 최평화 (울산대학교) 박인자 (울산대학교) 유창식 (울산대학교) 김진천 (울산대학교)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.24 No.4

발행연도: 2008.1

수록면: 265 - 272 (8page)

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이 논문의 연구 히스토리 (2)

2011

[Free Paper] 폐색성 대장암환자에서 대장절제 후 단단계 즉시문합술은 안전한가?

정상훈 , 김소현 , 김재황 대한외과학회 학술대회 초록집 2011.11 학술대회자료

2008

근치적 절제 후 1년 이내 조기 재발하는 대장암

정상훈 , 김희철 , 김아영 외 4명 Annals of Coloproctology 2008.01 학술저널

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Purpose: An individualized surveillance protocol based on stratified prognostic factors is needed for the early detection of recurrent disease. The aim of this study was to determine both the clinicopathological characteristics for early-recurring colorectal cancer and the impact on survival. Methods: From January 1996 to September 2000, 1,504 patients with curatively resected colorectal cancer were recruited. The primary goal of this study was to evaluate the time interval until first loco-regional or distant recurrence, and the secondary goal was the last survival status. Early recurrence was defined as recurrence within the first 12 months postoperatively. Clinicopathologic data and preoperative CT records were reviewed. The follow-up period was over 48 months. Results: The 5-year recurrence rate was 25.4%, and 39.5% of these were detected within the first 12 months postoperatively. In the multivariate analysis, the independent prognostic factors for early recurrence were cell differentiation (PD/MUC/SRC), lymphovascular invasion, and absence of adjuvant chemotherapy in stage III and curatively resected colorectal cancer in stage IV. Inaccurate interpretation by a low-quality CT scan resulted in a stage III cancer being understaged preoperatively. The 5-year overall survival rate according to the recurrent time interval was significantly different (early recurrence: 7.4% vs. late recurrence: 23.6%, P＜0.05). The resection rate was similar in both groups (early recurrence: 22.7% vs. late recurrence: 27.6%, P=0.392). Conclusions: Colorectal cancer that recurred within 12 months showed more aggressive biologic behaviors and poor survival. Understaging caused by incomplete preoperative evaluation for disease extension may cause treatment failure.

#Colorectal cancer #Early recurrence #Prognostic factor #Survival rate

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