지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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This study was focused on the evaluation of antioxidative effect of bitter melon (Momordica charantia L.). Bitter melon was extracted with methanol and then fractionated into 4 fractions (hexane, methylene chloride, ethyl acetate, and butanol fractions). The protective effect of bitter melon against oxidative stress was investigated under in vitro and cellular system. The extract and fractions from bitter melon exerted strong scavenging activity of 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical. Protective effects of bitter melon from nitric oxide (NO), and peroxynitrite under cellular oxidative stress model using LLC-PK1 cell were observed. The induction of oxidative stress by treatments of free radical generators led to the decrease in cell viability and elevation in NO formation. However, the treatment of fractions from bitter melon alleviated the oxidative stress by free radicals through increase in cell viability and inhibition in NO formation. The present study indicates that bitter melon alleviates oxidative stress and it plays as antioxidant. In particular, among the extract and fractions, the butanol fraction showed the highest protective effect from oxidative stress, suggesting that the butanol fraction from bitter melon includes the promising protective compounds from oxidative stress. (Cancer Prev Res 16, 86-92, 2011)
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참고문헌 (37)
참고문헌 신청
Oberley TD / 1995 / Antioxidant enzyme levels as a function of growth state in cell culture / Free Radic Biol Med 19:53~65
Stratton SP / 1997 / Determination of singlet oxygenspecific versus radical-mediated lipid peroxidation in photosensitized oxidation of lipid bilayers: effect of beta- carotene and alpha-tocopherol / Biochemistry 36:12911~12920
Schneider JE / 1990 / Methylene blue plus light mediates 8-hydroxy-2'-deoxyguanosine formation in DNA preferentially over strand breakage / Nucleic Acids Res 18:631~635
Rice-Evans C / 1993 / Free radical-lipid interaction and their pathological consequences / Prog Lipid Res 32:71~110
Wright AW / 2002 / Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues / Photochem Photobilo 76:35~46
Stratton SP / 1997 / Determination of singlet oxygenspecific versus radical-mediated lipid peroxidation in photosensitized oxidation of lipid bilayers: effect of beta- carotene and alpha-tocopherol / Biochemistry 36:12911~12920
Schneider JE / 1990 / Methylene blue plus light mediates 8-hydroxy-2'-deoxyguanosine formation in DNA preferentially over strand breakage / Nucleic Acids Res 18:631~635
Rice-Evans C / 1993 / Free radical-lipid interaction and their pathological consequences / Prog Lipid Res 32:71~110
Wright AW / 2002 / Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues / Photochem Photobilo 76:35~46
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