지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Magnetic resonance (MR) imaging has been widely used in the clinic because of the benefit of high spatial and temporal resolution, and the excellent anatomical tissue contrast. Cancer-targeted MR molecular imaging comprises 3 major components: a relevant molecular target which is specifically highly expressed on the membrane of the cancer cell; a target specific imaging probe which is composed of superparamagnetic iron oxide nanoparticle coreconjugated target specific ligand such as antibody, peptide, and molecules; MR imaging hardware and software which are sensitive to the imaging probe. Among the various molecular targets, HER2/neu receptor antibody, folic acid, and arginine-glycine-aspartic acid (RGD) are well known targeting ligands. The sensitivity of the cancer-targeted MR imaging is affected by the magnetic susceptibility of the T2 contrast agent, resolution of the image, targeting efficiency of the imaging probe, and image acquisition pulse sequence. Recently, successful cancer-targeted MR imaging with T1 contrast agent and cancer-specific molecular MR imaging using innate contrast of the cancer cell by chemical exchange phenomenon without using the imaging probe has been introduced. Cancer-targeted MR molecuar imaging is a robust diagnostic method to detect cancer at the cellular stage of the cancer development and it would help improve early detection rate of the cancer.
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참고문헌 (13)
참고문헌 신청
Weissleder R / 2001 / Molecular imaging / Radiology 219:316~333
Nahta R / 2003 / HER-2-targeted therapy: lessons learned and future directions / Clin Cancer Res 9:5078~5084
Reddy JA / 1998 / Folate-mediated targeting of the -rapeutic and imaging agents to cancers / Crit Rev Ther Drug Carrier Syst 15:587~627
Beer AJ / 2008 / Imaging of integrin alphavbeta3 expression / Cancer Metastasis Rev 27:631~644
Shin J / 2009 / Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery / Angew Chem Int Ed Engl 48:321~324
Nahta R / 2003 / HER-2-targeted therapy: lessons learned and future directions / Clin Cancer Res 9:5078~5084
Reddy JA / 1998 / Folate-mediated targeting of the -rapeutic and imaging agents to cancers / Crit Rev Ther Drug Carrier Syst 15:587~627
Beer AJ / 2008 / Imaging of integrin alphavbeta3 expression / Cancer Metastasis Rev 27:631~644
Shin J / 2009 / Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery / Angew Chem Int Ed Engl 48:321~324
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