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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 744 - 753 (10page)
이용수
이 논문의 연구 히스토리 (6)
2022
The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22e26-month-old C57BL/6J mice
Hyun-Ji Oh
,
Heegu Jin
,
Boo-Yong Lee
Journal of Ginseng Research
2022.11
학술저널
Silk Peptide Improves Sarcopenia in 22-26-month-old C57BL/6 mice
Hyun-Ji Oh
,
Heegu Jin
,
Hyein Han
외 1명
한국식품영양과학회 학술대회발표집
2022.10
학술대회자료
2021
Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20- to 24-month-old C57BL/6J mice
Hyun-Ji Oh
,
Heegu Jin
,
Seung-Yeol Nah
외 1명
Journal of Ginseng Research
2021.11
학술저널
Non-Saponin Fraction of Korean Red Ginseng Regulates Immunosenescence in 20- to 24-Month-Old C57BL/6J Mice
Hyun-Ji Oh
,
Heegu Jin
,
Hyeonji Woo
외 2명
한국식품영양과학회 학술대회발표집
2021.10
학술대회자료
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초록· 키워드
오류제보하기
Background: Gintonin-enriched fraction (GEF) is a new non-saponin component glycolipoprotein isolated from ginseng root. This study examined the effect of GEF on age-related sarcopenia in old C57BL/6J mice.
Methods: Young (3e6 months) and old (20e24 months) C57BL/6J mice received oral GEF (50 mg/kg/day or 150 mg/kg/day) daily for 5 weeks. During the oral administration period, body weight and grip strength were measured weekly. After sacrifice, muscles from the hindlimb were excised and used for hematoxylin and eosin staining and western blotting to determine the effects of GEF on sarcopenia. The thymus was photographed to compare size, and flow cytometry was performed to examine the effect of GEF on immune homeostasis in the thymus and spleen. Blood samples were collected, and the concentrations of pro-inflammatory cytokines and IGF-1 were measured.
Results: GEF caused a significant increase in muscle strength, mass, and fiber size in old mice. GEF restored age-related disruption of immune homeostasis by maintaining T cell compartments and regulating inflammatory biomarkers. Thus, GEF reduced common low-grade chronic inflammatory parameters, which are the main cause of muscle loss.
Conclusion: GEF maintained immune homeostasis and inhibited markers of chronic inflammation, resulting in anti-sarcopenia effects in aged C57BL/6J mice. Thus, GEF is a potential therapeutic agent that slows sarcopenia in the elderly.
Methods: Young (3e6 months) and old (20e24 months) C57BL/6J mice received oral GEF (50 mg/kg/day or 150 mg/kg/day) daily for 5 weeks. During the oral administration period, body weight and grip strength were measured weekly. After sacrifice, muscles from the hindlimb were excised and used for hematoxylin and eosin staining and western blotting to determine the effects of GEF on sarcopenia. The thymus was photographed to compare size, and flow cytometry was performed to examine the effect of GEF on immune homeostasis in the thymus and spleen. Blood samples were collected, and the concentrations of pro-inflammatory cytokines and IGF-1 were measured.
Results: GEF caused a significant increase in muscle strength, mass, and fiber size in old mice. GEF restored age-related disruption of immune homeostasis by maintaining T cell compartments and regulating inflammatory biomarkers. Thus, GEF reduced common low-grade chronic inflammatory parameters, which are the main cause of muscle loss.
Conclusion: GEF maintained immune homeostasis and inhibited markers of chronic inflammation, resulting in anti-sarcopenia effects in aged C57BL/6J mice. Thus, GEF is a potential therapeutic agent that slows sarcopenia in the elderly.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (59)
참고문헌 신청
Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : report of the European working group on sarcopenia in older people / Age Ageing 39(4):412~423
Visser M / 2011 / Consequences of sarcopenia / Clin Geriatr Med 27(3):387~399
Visser M / 2011 / Obesity, sarcopenia and their functional consequences in old age / Proc Nutr Soc 70(1):114~118
Ziaaldini MM / 2017 / Biochemical pathways of sarcopenia and their modulation by physical exercise : a narrative review / Front Med(Lausanne) 4:167
Bonaldo P / 2013 / Cellular and molecular mechanisms of muscle atrophy / Dis Model Mech 6(1):25~39
Visser M / 2011 / Consequences of sarcopenia / Clin Geriatr Med 27(3):387~399
Visser M / 2011 / Obesity, sarcopenia and their functional consequences in old age / Proc Nutr Soc 70(1):114~118
Ziaaldini MM / 2017 / Biochemical pathways of sarcopenia and their modulation by physical exercise : a narrative review / Front Med(Lausanne) 4:167
Bonaldo P / 2013 / Cellular and molecular mechanisms of muscle atrophy / Dis Model Mech 6(1):25~39
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UCI(KEPA) : I410-ECN-0101-2022-524-001133069