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논문 기본 정보

자료유형
학술저널
저자정보
Tae Su Seo (Sungyibio) Jae Hoon Lee (Sungyibio) Seung Tae Lim (Sungyibio) Deug Chan Lee (Kangwon National University) Joon Hee Han (Chuncheon Bioindustry Foundation) Min Hong (Chuncheon Bioindustry Foundation) Da Hye Choi (Chuncheon Bioindustry Foundation) Sun Yeop Lee (Chuncheon Bioindustry Foundation) Jae Hak Lee (Adbiotech) Keun Hyung Yu (Adbiotech)
저널정보
한국약용작물학회 한국약용작물학회지 한국약용작물학회지 제30권 제2호
발행연도
2022.4
수록면
145 - 152 (8page)
DOI
10.7783/KJMCS.2022.30.2.145

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초록· 키워드

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Background: Given the reported pharmacological effects of rutin from asparagus stems and roots, here, we assessed the anti-hangover and anti-gout effects of asparagus stem and root extracts.
Methods and Results: We found that rutin amount in ethanol extracts of asparagus stems was 10.15 ㎎/g, and in hydrothermal extracts of asparagus roots it was 3.28 ㎎/g. Alcohol dehydrogenase and aldehyde dehydrogenase activities in asparagus-stem extracts were 80% and 40% of those in the control group, respectively. Following hangover induction in rats using alcohol, an injection of 400 ㎎/㎏ body weight (BW) of the extract significantly reduced the blood alcohol concentration compared to that of the control group. Additionally, blood gamma-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) concentrations measured 5 h after alcohol administration revealed that treatment with 400 ㎎/㎏ BW of extract significantly reduced GGT and GOT concentrations compared to the control group, whereas changes in GPT were not significant. Moreover, xanthine oxidase activity after treatment with hydrothermal extracts of asparagus roots was 44.01 ± 0.32%, showing 53.3% inhibition compared to the positive control (allopurinol; 82.50 ± 4.98%). To assess the anti-gout effect of hydrothermal extracts of asparagus roots, we induced gout in rats by intraperitoneal injection of potassium oxonate and measured blood uric acid, creatinine, and blood urea nitrogen concentrations at 3 h post-administration of the extract. The results showed a significant reduction in creatinine and uric acid levels in the treated group compared to the control.
Conclusions: These findings demonstrated the potential of asparagus stem and root extracts as functional ingredients.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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