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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.5
- 수록면
- 396 - 407 (12page)
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이 논문의 연구 히스토리 (4)
2021
Rhein suppresses colorectal cancer cell growth by inhibiting the mTOR pathway in vitro and in vivo
Haibo Zhang
,
Zae Young Ryoo
,
Myoung Ok Kim
한국실험동물학회 학술발표대회 논문집
2021.07
학술대회자료
20(S)-ginsenoside Rh2 inhibits colorectal cancer cell proliferation, migration, and invasion through suppressing Axl signaling pathway
Haibo Zhang
,
Myoung ok Kim
한국실험동물학회 학술발표대회 논문집
2021.01
학술대회자료
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- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
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초록· 키워드
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Background: Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo.
Methods: Cell proliferation, migration, invasion, apoptosis, cell cycle, and western blot assays were performed to evaluate the effect of G-Rh2 on CRC cells. In vitro pull-down assay was used to verify the interaction between G-Rh2 and Axl. Transfection and infection experiments were used to explore the function of Axl in CRC cells. CRC xenograft models were used to further investigate the effect of Axl knockdown and G-Rh2 on tumor growth in vivo.
Results: G-Rh2 significantly inhibited proliferation, migration, and invasion, and induced apoptosis and G0/G₁ phase cell cycle arrest in CRC cell lines. G-Rh2 directly binds to Axl and inhibits the Axl signaling pathway in CRC cells. Knockdown of Axl suppressed the growth, migration and invasion ability of CRC cells in vitro and xenograft tumor growth in vivo, whereas overexpression of Axl promoted the growth, migration, and invasion ability of CRC cells. Moreover, G-Rh2 significantly suppressed CRC xenograft tumor growth by inhibiting Axl signaling with no obvious toxicity to nude mice.
Conclusion: Our results indicate that G-Rh2 exerts anticancer activity in vitro and in vivo by suppressing the Axl signaling pathway. G-Rh2 is a promising candidate for CRC prevention and treatment.
Methods: Cell proliferation, migration, invasion, apoptosis, cell cycle, and western blot assays were performed to evaluate the effect of G-Rh2 on CRC cells. In vitro pull-down assay was used to verify the interaction between G-Rh2 and Axl. Transfection and infection experiments were used to explore the function of Axl in CRC cells. CRC xenograft models were used to further investigate the effect of Axl knockdown and G-Rh2 on tumor growth in vivo.
Results: G-Rh2 significantly inhibited proliferation, migration, and invasion, and induced apoptosis and G0/G₁ phase cell cycle arrest in CRC cell lines. G-Rh2 directly binds to Axl and inhibits the Axl signaling pathway in CRC cells. Knockdown of Axl suppressed the growth, migration and invasion ability of CRC cells in vitro and xenograft tumor growth in vivo, whereas overexpression of Axl promoted the growth, migration, and invasion ability of CRC cells. Moreover, G-Rh2 significantly suppressed CRC xenograft tumor growth by inhibiting Axl signaling with no obvious toxicity to nude mice.
Conclusion: Our results indicate that G-Rh2 exerts anticancer activity in vitro and in vivo by suppressing the Axl signaling pathway. G-Rh2 is a promising candidate for CRC prevention and treatment.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
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20(S)-ginsenoside Rh2 inhibits colorectal cancer cell proliferation, migration, and invasion through suppressing Axl signaling pathway
한국실험동물학회 학술발표대회 논문집
2021 .01
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20 (S)-ginsenoside Rh2 exerts anti-cancer activity through the Axl signaling pathway in colorectal cancer cells
한국실험동물학회 학술발표대회 논문집
2022 .07
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Axl signaling suppression by 20(S)-Ginsenoside Rh2: a therapeutic strategy for colorectal cancer
한국실험동물학회 학술발표대회 논문집
2025 .02
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한국실험동물학회 학술발표대회 논문집
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(20s) Ginsenoside Rh2 suppress colorectal cancer cell growth by Axl signal pathway in vitro and in vivo
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Rhein suppresses colorectal cancer cell growth by inhibiting the mTOR pathway in vitro and in vivo
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The molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on anti-angiogenesis in cancer treatment: The battle between PI3K and ROS
Journal of Ginseng Research
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Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
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The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
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Sex hormone-binding globulin inhibits the entry of zoonotic coronavirus via AXL
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Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells
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Attitudes Towards Colorectal Cancer (CRC) and CRC Screening Tests among Elderly Malay Patients
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MicroRNA-362 Inhibits Cell Proliferation and Invasion by Directly Targeting SIX1 in Colorectal Cancer
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Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-kB and MAPK-Nrf2/NF-kB pathways
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Ginsenoside-Rh2 Inhibits Proliferation and Induces Apoptosis of Human Gastric Cancer SGC-7901 Side Population Cells
Asian Pacific journal of cancer prevention : APJCP
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Perioperative and Long-Term Oncological Outcomes of Laparoscopic RH with Comparison to Open RH
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The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts
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UCI(KEPA) : I410-ECN-0101-2022-524-001328751