Proteomic and Immunological Identification of Diagnostic Antigens from Spirometra erinaceieuropaei Plerocercoid

Yan Lu; Jia-Hui Sun; Li-Li Lu; Jia-Xu Chen; Peng Song; Lin Ai; Yu-Chun Cai; Lan-Hua Li; Shao-Hong Chen

추천

검색

질문

자료유형: 학술저널

저자정보: Yan Lu (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)) Jia-Hui Sun (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)) Li-Li Lu (The Third Hospital of Shijiazhuang City) Jia-Xu Chen (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)) Peng Song (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)) Lin Ai (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)) Yu-Chun Cai (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)) Lan-Hua Li (Weifang Medical University) Shao-Hong Chen (Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research))

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.59 No.6

발행연도: 2021.12

수록면: 615 - 623 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Human sparganosis is a food-borne parasitic disease caused by the plerocercoids of Spirometra species. Clinical diagnosis of sparganosis is crucial for effective treatment, thus it is important to identify sensitive and specific antigens of plerocercoids. The aim of the current study was to identify and characterize the immunogenic proteins of Spirometra erinaceieuropaei plerocercoids that were recognized by patient sera. Crude soluble extract of the plerocercoids were separated using 2-dimensional gel electrophoresis coupled with immunoblot and mass spectrometry analysis. Based on immunoblotting patterns and mass spectrometry results, 8 antigenic proteins were identified from the plerocercoid. Among the proteins, cysteine protease protein might be developed as an antigen for diagnosis of sparganosis.

#Spirometra erinaceieuropaei #plerocercoid #immunoproteomic #diagnosis #antigen

참고문헌 (68)

참고문헌 신청

Liu Q / 2015 / Human sparganosis, a neglected food borne zoonosis / Lancet Infect Dis 15:1226~1235

Ming-Wei Li / 2011 / Sparganosis in mainland China / International Journal of Infectious Diseases 15(3):e154~e156

김정근 / 2018 / Human Sparganosis in Korea / Journal of Korean Medical Science 33(44):1~15

Magnino S / 2009 / Biological risks associated with consumption of reptile products / Int J Food Microbiol 134:163~175

전형규 / 2015 / Human Infections with Spirometra decipiens Plerocercoids Identified by Morphologic and Genetic Analyses in Korea / The Korean Journal of Parasitology 53(3):299~305

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Yan Lu

소속기관 Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)