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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 137 - 142 (6page)
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초록· 키워드
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Enterovirus is a common cause of several severe diseases such as myocarditis, hand-foot-mouth disease, and meningitis in children and adult. There are many try to develop new antiviral drug for direct treatment in virus infection. However, synthetic chemical antiviral drug is not working. To overcome this limitation, we examined plant extracts. The antiviral effect of plant extracts was screened by HeLa cell survival assay in coxsackievirus B3 (CVB3) infection. We observed a strong antiviral effect of Poria cocos extract in a dose-dependent manner (1 mg/ml~0.01 mg/ml). P. cocos extract (1 mg/ml) treatment was dramatically decreased virus protease 2A induced eIF4G-I cleavage and virus capsid protein VP1 production. CVB3 positive and negative strand RNA amplification were significantly reduced in P. cocos extract treatment. P. cocos extract completely blocked early time activation of ERK and AKT activity in CVB3 infection. Taken together these data indicate that the treatment of P. cocos extract strongly inhibit CVB3 replication. Poria cocos extract may possible to developed as a therapeutic agent for enterovirus.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Feldman, A. M. / 2000 / Myocarditis / N. Engl. J. Med 343:1388~1398
Lim, B. K. / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest. 118:2758~2770
Knowlton, K. U. / 1996 / A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3 / J. Virol. 70:7811~7818
Knowlton, K. U. / 1999 / The immune system in viral myocarditis: maintaining the balance / Circ. Res. 85:559~561
Xiong, D. / 2007 / Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy / Circulation 115:94~102
Lim, B. K. / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest. 118:2758~2770
Knowlton, K. U. / 1996 / A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3 / J. Virol. 70:7811~7818
Knowlton, K. U. / 1999 / The immune system in viral myocarditis: maintaining the balance / Circ. Res. 85:559~561
Xiong, D. / 2007 / Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy / Circulation 115:94~102
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