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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 343 - 351 (9page)
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초록· 키워드
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The purpose of this study was to evaluate the whitening effect of aerial part of Pueraria lobata and mechanisms. Aerial part of Pueraria lobata, dose-dependently reduced the melanin content. Aerial part of Pueraria lobata, significantly decreased cellular tyrosinase activity, while there was not any effect on tyrosinase in cell-free conditions. To elucidate the mech-anisms behind the aerial part of Pueraria lobata, treated melanogenesis regulation, the expressions of melanogensis related genes, proteins, and the activity of α-glucosidase were determined. Aerial part of Pueraria lobata, significantly inhibited gene and protein levels of MITF, tyrosinase and TRP-1. It suppressed the α-glucosidase, leading to inhibition on the maturation of tyrosinase. Also aerial part of Pueraria lobata, was observed to have the high antioxidant activity. These results suggested that whitening effect of aerial part of Pueraria lobata, should be due to the down-regulation of MITF, tyrosinase and TRP-1 expression and the intercepting maturation of tyrosinase through suppressing α-glucosidase. Another should be the high anti-oxidant activity. The findings show the possibility that aerial part of Pueraria lobata, can be used as a potential skin-whit-ening agent.
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참고문헌 (38)
참고문헌 신청
Jun, H. J. / 2012 / Dual inhibition of γ-Oryzanol on cellular melanogenesis: inhibition of tyrosinase activity and reduction of melanogenic gene expression by a protein kinase A-dependent mechanism / J. Nat. Prod. 75:1706~1711
Yoon, N. Y. / 2009 / Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells / J. Agric. Food Chem. 57:4124~4129
이상민 / 2011 / 호장으로부터 분리한 Polydatin의 미백 및 주름억제 효능에 대한 연구 / 대한화장품학회지 37(4):327~335
Ye, Y. / 2010 / Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells / Phytomedicine 18:32~35
Soo-Yeon Lee / 2013 / Down-regulation of Tyrosinase, MITF, TRP-1, and TRP-2 Expressions by Juniperus rigida Sieb. in Murine B16F10 Melanoma / Journal of Life Science 23(12):1445~1453
Yoon, N. Y. / 2009 / Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells / J. Agric. Food Chem. 57:4124~4129
이상민 / 2011 / 호장으로부터 분리한 Polydatin의 미백 및 주름억제 효능에 대한 연구 / 대한화장품학회지 37(4):327~335
Ye, Y. / 2010 / Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells / Phytomedicine 18:32~35
Soo-Yeon Lee / 2013 / Down-regulation of Tyrosinase, MITF, TRP-1, and TRP-2 Expressions by Juniperus rigida Sieb. in Murine B16F10 Melanoma / Journal of Life Science 23(12):1445~1453
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