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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 305 - 311 (7page)
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초록· 키워드
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Osteoarthritis (OA) is the most common form of joint disease, characterized by articular cartilage, osteonecrosis, and osteochondral bone erosion. It is an early, progressive disease that combines joint stiffness and joint pain and reduces cartilage function and condition. Interleukin-1 beta (IL-1β) is thought to be important to the pathogenesis of OA and significantly increases the expression of matrix metalloproteinases (MMPs), which play an important role in cartilage degradation in OA. Sparassis crispa (Wulf.) is an edible / medicinal mushroom that has been reported to variety of biological activities. In this study, investigated the Anti-inflammatory effect of Sparassis crispa (Wulf.) ethanol extract (SCE) on IL-1β stimulated SW1353 chondrocytes. SCE decreased the expression and activity of MMPs by IL-1β and decreased the levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) associated with the inhibition of prostaglandin E2(PGE<sub>2</sub>) in IL-1β stimulated SW-1353 chondrocytes. In addition, SCE inhibits the expression of MAPK (mitogen-activated protein kinase) and NF-κB (nuclear factor-kappa B) signaling in IL-1β stimulated SW-1353 cells, and SCE inhibits the production of reactive oxygen species (ROS) through heme oxygenase-1 (HO-1) expression. Thus, it is suggested that SCE has a potential as an anti-inflammatory agent in osteoarthritis treatments.
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참고문헌 (29)
참고문헌 신청
손영옥 / 2018 / Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis / BMB Reports 51(4):165~166
Hochberg, M. / 2013 / Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate:What’s the evidence / Curr Med Res Opin 29:259~267
Martel, P. J. / 2008 / Cartilage in normal and osteoarthritis conditions / Best Pract. Res. Clin. Rheumatol 22:351~384
Fernandes, J. C. / 2002 / The role of cytokines in osteoarthritis pathophysiology / Biorheology 39:237~246
Abramson, S. B. / 2001 / Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis / Curr Rheumatol. Rep 3:535~541
Hochberg, M. / 2013 / Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate:What’s the evidence / Curr Med Res Opin 29:259~267
Martel, P. J. / 2008 / Cartilage in normal and osteoarthritis conditions / Best Pract. Res. Clin. Rheumatol 22:351~384
Fernandes, J. C. / 2002 / The role of cytokines in osteoarthritis pathophysiology / Biorheology 39:237~246
Abramson, S. B. / 2001 / Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis / Curr Rheumatol. Rep 3:535~541
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