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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 226 - 233 (8page)
이용수
초록· 키워드
오류제보하기
Antimicrobial peptides (AMPs) are now used instead of conventional antimicrobial substances because they do not induce resistance in microbial cells. The first goal of this study was to investigate how various dissolution solvents, such as dimethyl sulfoxide (DMSO), phosphate buffered saline (PBS) and autoclaved deionized (DI) water, affect the antimicrobial potency of an AMP (HHC-36) modified with L -propargylglycine (PraAMP) against Pseudomonas aeruginosa PAO1, Escherichia coli, and Bacillus sp. The potential application of HHC-36 AMP as a biofouling control agent on water treatment membranes was then investigated using a membrane fouling bacterium as a model. At concentrations greater than 0.5 mg/mL, the AMP demonstrated significant antibacterial efficacy against all the bacteria species. However, the initial dissolution of the HHC-36 AMP in DMSO had a significant impact on its antibacterial effects. DMSO alone (≥ 12.4% vol/vol) exhibited a significant bacterial growth inhibition. This finding is noteworthy because DMSO is commonly used as a solvent for antimicrobial agents that are insoluble in water. Overall, by disrupting bacterial cell membranes, the HHC-36 AMP was able to inactivate bacterial cells on water treatment membrane. This study recapitulates the feasible use of environmentally friendly AMP as antibiofouling agents in water treatment processes.
목차
ABSTRACT
1. Introduction
2. Materials and Methods
3. Results and Discussion
4. Conclusions
References
참고문헌 (40)
참고문헌 신청
Alayande AB, Aung MM, Kim IS. Correlation between quorum sensing signal molecules and Pseudomonas aeruginosa’s biofilm development and virulency. Curr. Microbiol. 2018;75: 787-793. https://doi.org/10.1007/s00284-018-1449-5
Flemming HC. Microbial biofouling: unsolved problems, insufficient approaches, and possible solutions. In Biofilm highlights. Springer; 2011. p. 81-109. https://doi.org/10.1007/978-3-642-19940-0_5
Alayande AB, Kim LH, Kim IS. Cleaning efficacy of hydroxypropyl-beta-cyclodextrin for biofouling reduction on reverse osmosis membranes. Biofouling 2016;32:359-370. https://doi.org/10.1080/08927014.2016.1151008
Komlenic R. Rethinking the causes of membrane biofouling. Filtr. Sep. 2010;47:26-28. https://doi.org/10.1016/S0015-1882(10)70211-1
Flemming HC. Reverse osmosis membrane biofouling. Exp. Therm Fluid Sci. 1997;14:382-391. https://doi.org/10.1016/S0894-1777(96)00140-9
Flemming HC. Microbial biofouling: unsolved problems, insufficient approaches, and possible solutions. In Biofilm highlights. Springer; 2011. p. 81-109. https://doi.org/10.1007/978-3-642-19940-0_5
Alayande AB, Kim LH, Kim IS. Cleaning efficacy of hydroxypropyl-beta-cyclodextrin for biofouling reduction on reverse osmosis membranes. Biofouling 2016;32:359-370. https://doi.org/10.1080/08927014.2016.1151008
Komlenic R. Rethinking the causes of membrane biofouling. Filtr. Sep. 2010;47:26-28. https://doi.org/10.1016/S0015-1882(10)70211-1
Flemming HC. Reverse osmosis membrane biofouling. Exp. Therm Fluid Sci. 1997;14:382-391. https://doi.org/10.1016/S0894-1777(96)00140-9
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