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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 310 - 316 (7page)
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Kyung-Ok-Go (KOK) is a traditional prescription used for debilitating natural aging and post-illness debilitation. KOK has been used in a variety of ways because it strengthens immunity, prevents illness, and helps recovery in case of illness. In particular, recent research has revealed that KOK helps improve memory and cognition. Therefore, in this study, we investigated whether KOK was effective in improving memory decline and depression-state observed during menopause. In the present study, we employed ovariectomized mouse as an animal model for measuring menopausal syndrome. The administration of KOK for 8 weeks, the object recognition memory and working memory were improved in novel object recognition test and Y-maze test. And in the forced swimming test, the immobility time were decreased. Additionally, the expression level of mature brain derived neurotropic factor (mBDNF) was increased by KOK administration in ovariectomized mouse hippocampus. These results suggested that KOK could improve cognitive decline and depression during menopausal period, and it might be come from enhancing expression level of mBDNF in hippocampus.
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Abstract
재료 및 방법
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참고문헌 (28)
참고문헌 신청
qTakahashi, T. A. / 2015 / Menopause / Med. Clin. North Am. 99:521~534
Delamater, L. / 2018 / Management of the perimenopause / Clin. Obstet. Gynecol. 61:419~432
Rymer, J. / 2000 / "Extracts from "clinical evidence": Menopausal symptoms / BMJ 321:1516~1519
Vegunta, S. / 2020 / Androgen therapy in women / J. Women's Health (Larchmt) 29:57~64
Dizavandi, F. R. / 2019 / An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women / Post Reprod. Health 25:11~20
Delamater, L. / 2018 / Management of the perimenopause / Clin. Obstet. Gynecol. 61:419~432
Rymer, J. / 2000 / "Extracts from "clinical evidence": Menopausal symptoms / BMJ 321:1516~1519
Vegunta, S. / 2020 / Androgen therapy in women / J. Women's Health (Larchmt) 29:57~64
Dizavandi, F. R. / 2019 / An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women / Post Reprod. Health 25:11~20
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