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논문 기본 정보

자료유형
학술저널
저자정보
Chang Zoo Kim (Kosin University College of Medicine) Sang Joon Lee (Kosin University College of Medicine) Sang Seok Hwang (Pukyong National University) Yu-Gyeong Chae (Pukyong National University) Daa Young Kwon (Kosin University Gospel Hospital) Taek Yong Ko (Kosin University Gospel Hospital) Jun Hyeong Kim (Kosin University College of Medicine) Min Jung Jung (Kosin University College of Medicine) Rangarirai Masanganise (University of Zimbabwe College of Medicine) Chulho Oak (Kosin University Gospel Hospital) Yeh-Chan Ahn (Kosin University Gospel Hospital)
저널정보
한국광학회 Current Optics and Photonics Current Optics and Photonics Vol.5 No.3
발행연도
2021.6
수록면
311 - 321 (11page)

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초록· 키워드

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Indocyanine green (ICG) is a dye approved for use in clinical diagnostics. ICG remains in the intravascular space following intravenous administration, due to its ability to rapidly bind to the plasma proteins, and its therapeutic potential has been studied in well-vascularized cutaneous tumors. Here we have evaluated the clinical response of a subconjunctival tumor to photothermal therapy (PTT) using an ICG-enhanced near-infrared diode laser and its adverse effects, in a rabbit. 22 male New Zealand white rabbits with subconjunctival tumors were enrolled (control group 6, laser-only group 8, laser-with-ICG group 8). Rabbits in the laser-with-ICG group received ICG (twice, 2 mg/kg each time, intravenously) directly followed by irradiation with a diode laser (λ = 810 nm). Rabbits in the laser-only group were irradiated with the diode laser. ICG angiography, ultrasonography, and pathologic examination were performed to evaluate PTT response at specific time points (0, 2, and 4 weeks after PTT). Two weeks after initial treatment, the eight rabbits treated by laser with ICG showed a 100% response rate. There was no clinical response in both laser-only and control groups. ICG-PTT is a potential and effective palliative therapeutic modality for subconjunctival tumors.

목차

Ⅰ. INTRODUCTION
Ⅱ. METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
Ⅴ. CONCLUSION
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