지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 311 - 321 (11page)
이용수
초록· 키워드
오류제보하기
Indocyanine green (ICG) is a dye approved for use in clinical diagnostics. ICG remains in the intravascular space following intravenous administration, due to its ability to rapidly bind to the plasma proteins, and its therapeutic potential has been studied in well-vascularized cutaneous tumors. Here we have evaluated the clinical response of a subconjunctival tumor to photothermal therapy (PTT) using an ICG-enhanced near-infrared diode laser and its adverse effects, in a rabbit. 22 male New Zealand white rabbits with subconjunctival tumors were enrolled (control group 6, laser-only group 8, laser-with-ICG group 8). Rabbits in the laser-with-ICG group received ICG (twice, 2 mg/kg each time, intravenously) directly followed by irradiation with a diode laser (λ = 810 nm). Rabbits in the laser-only group were irradiated with the diode laser. ICG angiography, ultrasonography, and pathologic examination were performed to evaluate PTT response at specific time points (0, 2, and 4 weeks after PTT). Two weeks after initial treatment, the eight rabbits treated by laser with ICG showed a 100% response rate. There was no clinical response in both laser-only and control groups. ICG-PTT is a potential and effective palliative therapeutic modality for subconjunctival tumors.
목차
Ⅰ. INTRODUCTION
Ⅱ. METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
Ⅴ. CONCLUSION
REFERENCES
참고문헌 (16)
참고문헌 신청
S. S. Hwang / 2013 / New model of subconjunctival tumor devel-opment in rabbits / J. Biomed. Opt 18:070501
T. S. Chinogurei / 2006 / Ocular surface squamous neoplasia (OSSN) and human immunodeficiency virus at Sekuru Kaguvi Eye Unit in Zimbabwe: the role of operational research studies in a resource poor environment? / Cent. Afr. J. Med 52:56~58
C. Abels / 1998 / Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi’s sarcoma / Br. J. Cancer 77:1021~1024
J. Denekamp / 1993 / Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy / BJR 66:181~196
P. Babilas / 2007 / Photothermolysis of blood vessels using indocyanine green and pulsed diode laser irradiation in the dorsal skinfold chamber model / Lasers Surg. Med 39:341~352
T. S. Chinogurei / 2006 / Ocular surface squamous neoplasia (OSSN) and human immunodeficiency virus at Sekuru Kaguvi Eye Unit in Zimbabwe: the role of operational research studies in a resource poor environment? / Cent. Afr. J. Med 52:56~58
C. Abels / 1998 / Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi’s sarcoma / Br. J. Cancer 77:1021~1024
J. Denekamp / 1993 / Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy / BJR 66:181~196
P. Babilas / 2007 / Photothermolysis of blood vessels using indocyanine green and pulsed diode laser irradiation in the dorsal skinfold chamber model / Lasers Surg. Med 39:341~352
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