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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 485 - 495 (11page)
이용수
초록· 키워드
오류제보하기
Photobiomodulation (PBM) using organic light emitting diodes (OLEDs) surface light sources have recently been claimed to be the next generation of PBM light sources. However, the differences between light emitting diodes (LEDs) and OLED mechanisms in vitro and in vivo have not been well studied. In vivo mouse models were used to investigate the effects of OLED irradiation on cellular function and cutaneous wound healing compared to LED irradiation. Mice in the LED- and OLED-irradiated groups were subjected to irradiation with 6 J/cm2 LED and OLED (630 nm), respectively, for 14 days after wounding, and some mice were sacrificed for the experiments on days 3, 7, 10, and 14. To evaluate wound healing, we performed hematoxylin-eosin and Masson’s trichrome staining and quantified collagen density by computerized image analysis. The results showed that the size of the wound, collagen density, neo-epidermis thickness, number of new blood vessels, and number of fibroblasts and neutrophils was significantly influenced by LED and OLED irradiation. The tissue levels of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α were investigated by immunohistochemical staining. LED and OLED irradiation resulted in a significant increase in the tissue IL-1β and IL-6 levels at the early stage of wound healing (P < 0.01), and a decrease in the tissue TNF-α level at all stages of wound healing (P < 0.05), compared to the no-treatment group. The expression levels of the genes encoding vascular endothelial growth factor and transforming growth factor-beta 1 were significantly increased in LED and OLED-irradiated wound tissue at the early stage of wound healing (P < 0.01) compared to the no-treatment group. Thus, OLED as well as LED irradiation accelerated wound healing by modulating the synthesis of anti-inflammatory cytokines and the expression levels of genes encoding growth factors, promoting collagen regeneration and reducing scarring. In conclusion, this suggests the possibility of OLED as a new light source to overcome the limitations of existing PBMs.
목차
I. INTRODUCTION
II. METHODS
III. RESULTS
IV. DISCUSSION
V. CONCLUSION
REFERENCES
참고문헌 (39)
참고문헌 신청
C. K. Sen / 2009 / Human skin wounds : a major and snowballing threat to public health and the economy / Wound Repair Regen 17:763~771
N. B. Menke / 2007 / Impaired wound healing / Clin. Dermatol 25:19~25
D. R. Bickers / 2006 / The burden of skin diseases : 2004 a joint project of the american academy of dermatology association and the society for investigative dermatology / J. Am. Acad. Dermatol 55:490~500
M. Takeo / 2015 / Wound healing and skin regeneration / Cold Spring Harbor Perspect. Med 5:a023267
R. Blakytny / 2006 / The molecular biology of chronic wounds and delayed healing in diabetes / Diabet. Med 23:594~608
N. B. Menke / 2007 / Impaired wound healing / Clin. Dermatol 25:19~25
D. R. Bickers / 2006 / The burden of skin diseases : 2004 a joint project of the american academy of dermatology association and the society for investigative dermatology / J. Am. Acad. Dermatol 55:490~500
M. Takeo / 2015 / Wound healing and skin regeneration / Cold Spring Harbor Perspect. Med 5:a023267
R. Blakytny / 2006 / The molecular biology of chronic wounds and delayed healing in diabetes / Diabet. Med 23:594~608
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