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논문 기본 정보

자료유형
학술저널
저자정보
Geneva Rose Notario (Yonsei University College of Medicine) Kihyuck Kwak (Yonsei University College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.22 No.6
발행연도
2022.12
수록면
69 - 88 (20page)

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초록· 키워드

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In the face of an endlessly expanding repertoire of Ags, vaccines are constantly being tested, each more effective than the last. As viruses and other pathogens evolve to become more infectious, the need for efficient and effective vaccines grows daily, which is especially obvious in an era that is still attempting to remove itself from the clutches of the severe acute respiratory syndrome coronavirus 2, the cause of coronavirus pandemic. To continue evolving alongside these pathogens, it is proving increasingly essential to consider one of the main effector cells of the immune system. As one of the chief orchestrators of the humoral immune response, the B cell and other lymphocytes are essential to not only achieving immunity, but also maintaining it, which is the vital objective of every vaccine.

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ABSTRACT
AN INTRODUCTION TO THE B CELL
LIMITATIONS OF RECENT VACCINES
CANONICALLY DERIVED EFFECTOR B CELLS ARISE FROM BONE MARROW PRECURSORS
Ag SENSING BY THE BCR: THE INITIATION OF THE B-CELL MEDIATED IMMUNE RESPONSE
BCR CO-RECEPTORS AND TLRs MAY BE KEY MEDIATORS OF IMMUNE RESPONSES
THE GC REACTION
MBC POPULATIONS ARISE BEFORE AND DURING THE GC RESPONSE
LONG LIVED PCs PROVIDE HIGHLY SPECIFIC PROTECTION
MBCs RECALLED TO SECONDARY GCs MUST COMPETE WITH NAIVE B CELLS FOR GC ENTRY
MUCOSA-ASSOCIATED B CELLS ARE FRONTLINE GATEKEEPERS AGAINST EXOGENOUS Ags
INTEGRATION OF B CELL KNOWLEDGE ALLOWS FOR IMPROVED VACCINE DESIGNS
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