지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 1 - 12 (12page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Male hypogonadism is a condition where the body does not produce enough testosterone and significantly impacts health. Age, obesity, genetics, and oxidative stress are some physiological factors that may contribute to testosterone deficiency. Previous studies have shown many pharmacological benefits of Schisandra chinensis (S. chinensis) Baillon as an anti-inflammatory and antioxidant. However, the molecular mechanism of attenuating hypogonadism is yet to be well established. This research was undertaken to study the effects of S. chinensis extract (SCE) on testosterone deficiency.
MATERIALS/METHODS: S. chinensis fruit was pulverized and extracted using 60% aqueous ethanol. HPLC analysis was performed to analyze and quantify the lignans of the SCE.
RESULTS: The 2,2-diphenyl-2-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) scavenging assays confirmed that the SCE and its major lignans (schisandrol A and gomisin N) inhibit oxidative stress. Effects of SCE analysis on the testosterone level under oxidative stress conditions revealed that both schisandrol A and gomisin N were able to recover the lowered testosterone levels. Through mRNA expression of TM3 Leydig cell, we observed that the SCE lignans were able to induce the enzymes involved in testosterone biosynthesis-related genes such as 3β-HSD4 (P < 0.01 for SCE, and P < 0.001 for schisandrol A and gomisin N), 17β-HSD3 (P < 0.001 for SCE, schisandrol A and gomisin N), and 17, 20-desmolase (P < 0.01 for schisandrol A, and P < 0.001 for SCE and gomisin N).
CONCLUSIONS: These results support that SCE and its active components could be potential therapeutic agents for regulating and increasing testosterone production.
MATERIALS/METHODS: S. chinensis fruit was pulverized and extracted using 60% aqueous ethanol. HPLC analysis was performed to analyze and quantify the lignans of the SCE.
RESULTS: The 2,2-diphenyl-2-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) scavenging assays confirmed that the SCE and its major lignans (schisandrol A and gomisin N) inhibit oxidative stress. Effects of SCE analysis on the testosterone level under oxidative stress conditions revealed that both schisandrol A and gomisin N were able to recover the lowered testosterone levels. Through mRNA expression of TM3 Leydig cell, we observed that the SCE lignans were able to induce the enzymes involved in testosterone biosynthesis-related genes such as 3β-HSD4 (P < 0.01 for SCE, and P < 0.001 for schisandrol A and gomisin N), 17β-HSD3 (P < 0.001 for SCE, schisandrol A and gomisin N), and 17, 20-desmolase (P < 0.01 for schisandrol A, and P < 0.001 for SCE and gomisin N).
CONCLUSIONS: These results support that SCE and its active components could be potential therapeutic agents for regulating and increasing testosterone production.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Schisandrol A and gomisin N from Schisandra chinensis extract improve hypogonadism via anti-oxidative stress in TM3 Leydig cells
Nutrition Research and Practice
2023 .02
-
Preface to the SCES2023 Conference Proceedings
새물리
2023 .12
-
Schisandrin A in Schisandra chinensis Upregulates the LDL Receptor by Inhibiting PCSK9 Protein Stabilization in Steatotic Model
Journal of Microbiology and Biotechnology
2024 .02
-
Impact of Gate and Drain Distance on Device Characteristics in InAlGaN/GaN High Electron Mobility Transistors
Applied Science and Convergence Technology
2024 .09
-
Analysis of Dibenzocyclooctadiene Lignans in Omija Wine and Cheong by Liquid Chromatography-Tandem Mass Spectrometry
Mass Spectrometry Letters
2020 .06
-
Gomisin A Ameliorates Endoplasmic Reticulum Stress-induced Hepatic Steatosis
생명과학회지
2017 .02
-
테스토스테론 물질 검출을 위한 in vitro TCD 시스템 구축
생명과학회지
2019 .10
-
Influence of various intensities of 528 Hz sound-wave in production of testosterone in rat’s brain and analysis of behavioral changes
Genes & Genomics
2019 .01
-
Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
Nutrition Research and Practice
2015 .10
-
Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
Nutrition Research and Practice
2015 .10
-
In vitro 검출 시스템을 이용한 한약재 열수 및 에탄올 추출물의 남성호르몬 유사활성 검출
생명과학회지
2020 .06
-
편백 잎에서 추출한 정유와 초임계 이산화탄소 추출물의 성분 비교분석
목재공학(Journal of the Korean Wood Science and Technology)
2015 .01
-
VDR mediated HSD3B1 to regulate lipid metabolism and promoted testosterone synthesis in mouse Leydig cells
Genes & Genomics
2022 .05
-
Inhibitory Effects of Dietary Schisandra Supplements on CYP3A Activity in Human Liver Microsomes
Mass Spectrometry Letters
2022 .12
-
흰민들레 발효추출물의 남성 갱년기 개선에 대한 효과
생명과학회지
2016 .09
-
Evalutation of MS-based metabolomics approaches for the discrimination of geographical variation of Schisandra chinensis
한국분석과학회 학술대회
2016 .05
-
GC/MS를 이용한 말의 뇨 중 Testosterone Enanthate 분석
한국분석과학회 학술대회
2015 .11
-
오미자 박, schizandrin 및 gomisin A에 의한 RAW264.7 세포주에서 lipopolysaccharide로 유도된 염증 반응의 억제
생명과학회지
2018 .03
-
Statistical effect analysis on the testosterone concentration, carcass grade and ultrasonic measurement at 30-month-old of Hanwoo steers
한국데이터정보과학회지
2018 .11
-
전립선비대증의 어성초추출물에 의한 경구투여 효과
생명과학회지
2019 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-594-000349392