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논문 기본 정보

자료유형
학술저널
저자정보
Song Minho (Division of Animal and Dairy Science Chungnam National University Daejeon 34134 Republic of Korea) Kim Byeonghyeon (Division of Animal and Dairy Science Chungnam National University Daejeon 34134 Republic of Korea) Cho Jin Ho (Division of Food and Animal Science Chungbuk National University Cheongju 28644 Republic of Korea) Kyoung Hyunjin (Division of Animal and Dairy Science Chungnam National University Daejeon 34134 Republic of Korea) Choe Jeehwan (Department of Beef Science Korea National College of Agriculture and Fisheries Jeonju 54874 Republi) Cho Jee-Yeon (DSM Nutrition Korea Ltd. Seoul 06675 Republic of Korea) Kim Younghoon (Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Se) 김현범 (단국대학교) Lee Jeong Jae (Division of Animal and Dairy Science Chungnam National University Daejeon 34134 Republic of KoreaIn)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제7호
발행연도
2022.7
수록면
885 - 891 (7page)
DOI
10.4014/jmb.2205.05033

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Plant-based protein sources such as soybean meal have low digestibility and are generally promoted accumulation of undigested proteins into the intestine by enzymatic treatments. Moreover, potential intestinal pathogens ferment undigested proteins, producing harmful substances, such as ammonia, amines and phenols, leading to an overactive immune response and diarrhea in weaned pigs. As a solution, dietary proteases hydrolyze soybean-based antinutritive factors, which negatively affect immune responses and gut microbiota. In this study, we investigated the effects of dietary proteases (PRO) in a low-crude protein (CP) commercial diet on the immune responses and gut microbiota of weaned pigs. The experimental design consisted of three dietary treatments: a commercial diet as a positive control (PC; phase1 CP = 23.71%; phase 2 CP: 22.36%), a lower CP diet than PC as negative control (NC; 0.61% less CP than PC), and NC diet supplement with 0.02% PRO. We found that PRO tended to decrease the frequency of diarrhea in the first two weeks after weaning compared with PC and NC. In addition, pigs fed PRO showed decreased TNF-α and TGF-β1 levels compared with those fed PC and NC. The PRO group had a higher relative proportion of the genus Lactobacillus and lower levels of the genus Streptococcus than the PC and NC groups. In conclusion, the addition of PRO to a low CP commercial weaned diet attenuated inflammatory responses and modified gut microbiota in weaned pigs.

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