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논문 기본 정보

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학술저널
저자정보
Zaharah Sulaiman (Women’s Health Development Unit, School of Medical Sciences, Health Campus, Universiti Sains Malays) Norhayati Mohd Noor (Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia) Shaiful Bahari Ismail (Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia) Anis Syahirah Far’ain Mohd Lukman (Women’s Health Development Unit, School of Medical Sciences, Health Campus, Universiti Sains Malays) Muhammad Irfan (Women’s Health Development Unit, School of Medical Sciences, Health Campus, Universiti Sains Malays) Nik Hazlina Nik Hussain (Women’s Health Development Unit, School of Medical Sciences, Health Campus, Universiti Sains Malays)
저널정보
대한가정의학회 Korean Journal of Family Medicine Korean Journal of Family Medicine 제43권 제3호
발행연도
2022.5
수록면
174 - 182 (9page)
DOI
10.4082/kjfm.21.0029

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Background: Vitamin D may enhance immune system function and provide a protective effect against infections. Feto-maternal circulation plays an important role in supplying the developing fetus with nutrients and antibodies for its development and health during pregnancy and for its early years of life after birth. This meta-analysis aimed to determine the effectiveness of maternal vitamin D supplementation in preventing respiratory tract infections (RTIs) in children.Methods: We searched the Central and MEDLINE databases and went through all the reference lists in the related articles. We also searched for ongoing trials at http://www.who.int/ictrp/en/ and www.clinicaltrials.gov. Random-ized controlled trials comparing vitamin D supplementation with a placebo or no treatment in pregnant women published in the English language up to March 2019 were included. Two reviewers extracted data independently using a predefined protocol and assessed the risk of bias using the Cochrane risk of bias tool, with differences agreed upon by consensus. The predefined primary outcome was the number of offspring who had RTIs. The sec-ondary outcome was the presence of measurable serum immunoglobulin E levels.Results: Three trials involving 3,224 participants (mother?child pairs) met the inclusion criteria and were included in this review. The present analysis reported that maternal supplementation with vitamin D had no effect on RTIs among children (n=1,486 offspring; risk ratio, 0.95; 95% confidence interval, 0.82?1.11; random effects; I2 statistics, 0%).Conclusion: Maternal vitamin D supplementation had no effect on RTIs in children. Therefore, consideration of other prevention methods in this regard is recommended.

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