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논문 기본 정보

자료유형
학술저널
저자정보
Lim Gina (Department of Pediatrics Ulsan University Hospital University of Ulsan College of Medicine Ulsan Ko) Kim Yoo Jinie (Department of Pediatrics Konkuk University Medical Center Seoul Korea.) Chung Sochung (Department of Pediatrics Konkuk University Medical Center Seoul Korea.Konkuk University School of M) Park Yong Mean (Department of Pediatrics Konkuk University Medical Center Seoul Korea.Konkuk University School of M) Kim Kyo Sun (Department of Pediatrics Konkuk University Medical Center Seoul Korea.) Park Hye Won (Department of Pediatrics Konkuk University Medical Center Seoul Korea.Konkuk University School of M)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.16
발행연도
2022.4
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2022.37.e127

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Background: This meta-analysis was performed to examine the association between maternal hypertension during pregnancy (HDP) and neonatal bronchopulmonary dysplasia (BPD). Methods: We systematically searched PubMed, EMBASE, the Cochrane Library, and the KoreaMed database for relevant studies. We used the Newcastle-Ottawa Scale for quality assessment of all included studies. The meta-analysis was performed using Comprehensive Meta-Analysis software (version 3.3). Results: We included 35 studies that fulfilled the inclusion criteria; the total number of infants evaluated came to 97,399 through review process. Maternal HDP was not significantly associated with any definition of BPD, i.e., oxygen dependency at 36 weeks of gestation (odds ratio [OR], 1.162; 95% confidence interval [CI], 0.991?1.362; P = 0.064) in pooled analysis of 29 studies or oxygen dependency at 28 days of age (OR, 1.084; 95% CI, 0.660?1.780; P = 0.751) in pooled analysis of 8 studies. Maternal HDP was significantly associated only with severe BPD (OR, 2.341; 95% CI, 1.726?3.174; P < 0.001). BPD was not associated with HDP in the overall analysis (OR, 1.131; 95% CI, 0.977?1.309; P = 0.100) or subgroup analysis according to the definition of HDP. Conclusion: Maternal HDP was not associated with neonatal BPD defined by the duration of oxygen dependency (at either 36 weeks of gestation or 28 days of life) but was associated with severe BPD.

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