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논문 기본 정보

자료유형
학술저널
저자정보
Jung Jiwon (Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul) Lee Jungmin (Department of Microbiology Institute for Viral Diseases Chung Mong-Koo Vaccine Innovation Center Co) Park Heedo (Department of Microbiology Institute for Viral Diseases Chung Mong-Koo Vaccine Innovation Center Co) Lim Young-Ju (Office for Infection Control Asan Medical Center Seoul Korea.) Kim Eun Ok (Office for Infection Control Asan Medical Center Seoul Korea.) Park Man-Seong (Department of Microbiology Institute for Viral Diseases Chung Mong-Koo Vaccine Innovation Center Co) Kim Sung-Han (Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.17
발행연도
2022.5
수록면
1 - 8 (8page)
DOI
10.3346/jkms.2022.37.e133

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초록· 키워드

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Background: The potential for a nosocomial outbreak of coronavirus disease 2019 (COVID-19) from a fully vaccinated individual is largely unknown. Methods: In October 2021, during the time when the delta variant was dominant, a nosocomial outbreak of COVID-19 occurred in two wards in a tertiary care hospital in Seoul, Korea. We performed airflow investigations and whole-genome sequencing (WGS) of the virus. Results: The index patient developed symptoms 1 day after admission, and was diagnosed with COVID-19 on day 4 post-admission. He was fully vaccinated (ChAdOx1 nCoV-19) 2 months before the diagnosis. Three inpatients and a caregiver in the same room, two inpatients in an adjacent room, two inpatients in rooms remote from the index room, and one nurse on the ward tested positive. Also, two resident doctors who stayed in an on-call room located on the same ward tested positive (although they had no close contact), as well as a caregiver who stayed on an adjacent ward, and a healthcare worker who had casual contact with this caregiver. Samples from five individuals were available for WGS, and all showed ≤ 1 single-nucleotide polymorphism difference. CCTV footage showed that the index case walked frequently in the corridors of two wards. An airflow study showed that the air from the corridor flowed into the resident on-call room, driven by an air circulator that was always turned on. Conclusion: Transmission of severe acute respiratory syndrome coronavirus 2 from a fully vaccinated index occurred rapidly via the wards and on-call room. Care must be taken to not use equipment that can change the airflow.

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