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자료유형
학술저널
저자정보
Lee Jong Eun (Department of Radiology Chonnam National University Medical School Chonnam National University Hosp) Jeong Won Gi (Department of Radiology Chonnam National University Medical School Chonnam National University Hwas) Nam Bo Da (Department of Radiology Soonchunhyang University Seoul Hospital Seoul Korea.) Yoon Soon Ho (Department of Radiology Seoul National University Hospital Seoul National College of Medicine Seoul) Jeong Yeon Joo (Department of Radiology and Biomedical Research Institute Pusan National University Hospital Busan) Kim Yun-Hyeon (Department of Radiology Chonnam National University Medical School Chonnam National University Hosp) Kim Sung Jin (Department of Radiology Chungbuk National University College of Medicine Chungbuk National Universi) Yoo Jin Young (Department of Radiology Chungbuk National University College of Medicine Chungbuk National Universi)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.22
발행연도
2022.6
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2022.37.e78

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Background: We analyzed the differences between clinical characteristics and computed tomography (CT) findings in patients with coronavirus disease 2019 (COVID-19) to establish potential relationships with mediastinal lymphadenopathy and clinical outcomes. Methods: We compared the clinical characteristics and CT findings of COVID-19 patients from a nationwide multicenter cohort who were grouped based on the presence or absence of mediastinal lymphadenopathy. Differences between clinical characteristics and CT findings in these groups were analyzed. Univariate and multivariate analyses were performed to determine the impact of mediastinal lymphadenopathy on clinical outcomes. Results: Of the 344 patients included in this study, 53 (15.4%) presented with mediastinal lymphadenopathy. The rate of diffuse alveolar damage pattern pneumonia and the visual CT scores were significantly higher in patients with mediastinal lymphadenopathy than in those without (P < 0.05). A positive correlation between the number of enlarged mediastinal lymph nodes and visual CT scores was noted in patients with mediastinal lymphadenopathy (Spearman’s ρ = 0.334, P < 0.001). Multivariate analysis showed that mediastinal lymphadenopathy was independently associated with a higher risk of intensive care unit (ICU) admission (odds ratio, 95% confidence interval; 3.25, 1.06-9.95) but was not significantly associated with an increased risk of in-hospital death in patients with COVID-19. Conclusion: COVID-19 patients with mediastinal lymphadenopathy had a larger extent of pneumonia than those without. Multivariate analysis adjusted for clinical characteristics and CT findings revealed that the presence of mediastinal lymphadenopathy was significantly associated with ICU admission.

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