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논문 기본 정보

자료유형
학술저널
저자정보
조아름 (부산대학교) 이현정 (부산대학교) 홍정민 (부산대학교) Kang Christine (Department of Anesthesiology and Pain Medicine Seoul National University Hospital) 김혜진 (부산대학교병원) Kim Eun-Jung (Department of Dental Anesthesia and Pain Medicine School of Dentistry) Kim Min Su (Department of Thoracic and Cardiovascular Surgery Kangbuk Samsung Hospital) Jeon Soeun (Department of Anesthesia and Pain Medicine Medical Research Institute Pusan National University Hos) Hwang Hyewon (Department of Anesthesiology and Pain Medicine Institution of Medical Research)
저널정보
대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.75 No.4
발행연도
2022.8
수록면
338 - 349 (12page)
DOI
10.4097/kja.22097

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Background: Microcirculatory disturbances are typically most severe during cardiopulmonary bypass (CPB), which occurs during cardiac surgeries. If microvascular reactivity compensates for microcirculatory disturbances during CPB, tissue hypoxemia can be minimized. The primary aim of this study was to assess whether microvascular reactivity during CPB could predict major adverse events (MAE) after cardiac surgery.Methods: This prospective observational study included 115 patients who underwent elective on-pump cardiac surgeries. A vascular occlusion test (VOT) with near-infrared spectroscopy was performed five times for each patient: before the induction of general anesthesia, 30 min after the induction of general anesthesia, 30 min after applying CPB, 10 min after protamine injection, and post-sternal closure. The postoperative MAE was recorded. The area under the receiver operating characteristic (AUROC) curve analysis was performed for the prediction of MAE using the recovery slope.Results: Of the 109 patients, MAE occurred in 32 (29.4%). The AUROC curve for the recovery slope during CPB was 0.701 (P < 0.001; 95% CI [0.606, 0.785]). If the recovery slope during CPB was < 1.08%/s, MAE were predicted with a sensitivity of 62.5% and specificity of 72.7%.Conclusions: Our study demonstrated that the recovery slope of the VOT during CPB could predict MAE after cardiac surgery. These results support the idea that disturbances in microcirculation induced by CPB can predict the development of poor clinical outcomes, thereby demonstrating the potential role of microvascular reactivity as an early predictor of MAE after cardiac surgery.

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