Quantification of Efflorescences in Pustular Psoriasis Using Deep Learning

Ludovic Amruthalingam; Oliver Buerzle; Philippe Gottfrois; Alvaro Gonzalez Jimenez; Anastasia Roth; Thomas Koller; Marc Pouly; Alexander A. Navarini

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자료유형: 학술저널

저자정보: Ludovic Amruthalingam (University of Basel) Oliver Buerzle (University Hospital Zurich) Philippe Gottfrois (University of Basel) Alvaro Gonzalez Jimenez (University of Basel) Anastasia Roth (Swiss Federal Institute of Technology) Thomas Koller (Lucerne University of Applied Sciences and Arts) Marc Pouly (Lucerne University of Applied Sciences and Arts) Alexander A. Navarini (University of Basel)

저널정보: 대한의료정보학회 Healthcare Informatics Research Healthcare Informatics Research 제28권 제3호

발행연도: 2022.7

수록면: 222 - 230 (9page)

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Objectives: Pustular psoriasis (PP) is one of the most severe and chronic skin conditions. Its treatment is difficult, and measurementsof its severity are highly dependent on clinicians’ experience. Pustules and brown spots are the main efflorescencesof the disease and directly correlate with its activity. We propose an automated deep learning model (DLM) to quantifylesions in terms of count and surface percentage from patient photographs. Methods: In this retrospective study, two dermatologistsand a student labeled 151 photographs of PP patients for pustules and brown spots. The DLM was trained andvalidated with 121 photographs, keeping 30 photographs as a test set to assess the DLM performance on unseen data. We alsoevaluated our DLM on 213 unstandardized, out-of-distribution photographs of various pustular disorders (referred to as thepustular set), which were ranked from 0 (no disease) to 4 (very severe) by one dermatologist for disease severity. The agreementbetween the DLM predictions and experts’ labels was evaluated with the intraclass correlation coefficient (ICC) for thetest set and Spearman correlation (SC) coefficient for the pustular set. Results: On the test set, the DLM achieved an ICC of0.97 (95% confidence interval [CI], 0.97?0.98) for count and 0.93 (95% CI, 0.92?0.94) for surface percentage. On the pustularset, the DLM reached a SC coefficient of 0.66 (95% CI, 0.60?0.74) for count and 0.80 (95% CI, 0.75?0.83) for surface percentage. Conclusions: The proposed method quantifies efflorescences from PP photographs reliably and automatically, enabling aprecise and objective evaluation of disease activity.

#Psoriasis #Dermatology #Computer-Assisted Diagnosis #Machine Learning #Deep Learning

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