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논문 기본 정보

자료유형
학술저널
저자정보
김진영 (Division of Endocrinology and Metabolism The Catholic University of Korea Korea) 김미경 (가톨릭대학교) 백기현 (가톨릭대학교) 송기호 (가톨릭대학교) 한경도 (숭실대학교) 권혁상 (가톨릭대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.37 No.2
발행연도
2022.4
수록면
303 - 311 (9page)
DOI
https://doi.org/10.3803/EnM.2021.1332

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Background: High-density lipoprotein cholesterol (HDL-C) plays an important role in the reverse cholesterol transport pathwayand prevents atherosclerosis-mediated disease. It has also been suggested that HDL-C may be a protective factor against cancer. However, an inverse correlation between HDL-C and cancer has not been established, and few studies have explored thyroid cancer. Methods: The study participants received health checkups provided by the Korean National Health Insurance Service from 2009 to2013 and were followed until 2019. Considering the variability of serum HDL-C level, low HDL-C level was analyzed by groupingbased on four consecutive health checkups. The data analysis was performed using univariate and multivariate Cox proportionalhazard regression models. Results: A total of 3,134,278 total study participants, thyroid cancer occurred in 16,129. In the crude model, the hazard ratios for theassociation between repeatedly measured low HDL-C levels and thyroid cancer were 1.243, 1.404, 1.486, and 1.680 (P for trend<0.01), respectively, which were significant even after adjusting for age, sex, lifestyle factors, and metabolic diseases. The subgroupanalysis revealed that low HDL-C levels likely had a greater impact on the group of patients with central obesity (P for interaction=0.062), high blood pressure (P for interaction=0.057), impaired fasting glucose (P for interaction=0.051), and hyperlipidemia(P for interaction=0.126). Conclusion: Repeatedly measured low HDL-C levels can be considered a risk factor for cancer as well as vascular disease. LowHDL-C levels were associated with the risk of thyroid cancer, and this correlation was stronger in a metabolically unhealthy population.

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