P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging

Haoran Wang; 강호만; Jason Dinh; Shinya Yokomizo; Wesley R. Stiles; Molly Tully; Kevin Cardenas; Surbhi Srinivas; Jason Ingerick; Sung Ahn; Kai Bao; 최학수

doi:https://doi.org/10.1186/s40824-022-00294-2

추천

검색

자료유형: 학술저널

저자정보: Haoran Wang (Wuya College of Innovation Shenyang Pharmaceutical University Shenyang China.) 강호만 (Harvard Medical School) Jason Dinh (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Shinya Yokomizo (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Wesley R. Stiles (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Molly Tully (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Kevin Cardenas (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Surbhi Srinivas (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Jason Ingerick (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Sung Ahn (Massachusetts General Hospital and Harvard Medical School Boston MA USA) Kai Bao (Massachusetts General Hospital and Harvard Medical School) 최학수 (사단법인 김해하버드바이오이미징센터)

저널정보: 한국생체재료학회 생체재료학회지 생체재료학회지 제26권 제4호

발행연도: 2022.12

수록면: 955 - 968 (14page)

DOI: https://doi.org/10.1186/s40824-022-00294-2

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advanta geous over conventional visible and NIR-I fluorescence imaging for the detection of bone growth, metabolism, metastasis, and other bone-related diseases. Methods: Bone-targeted heptamethine cyanine fluorophores were synthesized by substituting the meso-carbon with a sulfur atom, resulting in a bathochromic shift and increased fluorescence intensity. The physicochemical, opti cal, and thermal stability of newly synthesized bone-targeted NIR fluorophores was performed in aqueous solvents. Calcium binding, bone-specific targeting, biodistribution, pharmacokinetics, and 2D and 3D NIR imaging were per formed in animal models. Results: The newly synthesized S-substituted heptamethine fluorophores demonstrated a high affinity for hydroxyapatite and calcium phosphate, which improved bone-specific targeting with signal-background ratios > 3.5. Particularly, P800SO3-PEG showed minimum nonspecific uptake, and most unbound molecules were excreted into the urinary bladder. Histological analyses demonstrated that P800SO3-PEG remained stable in the bone for over two weeks and was incorporated into bone matrices. Interestingly, the flexible thiol ethylene glycol linker on P800SO3-PEG induced a promising photothermal effect upon NIR laser irradiation, demonstrating potential theranostic imaging. Conclusions: P800SO3-PEG shows a high affinity for bone tissues, deeper tissue imaging capabilities, minimum nonspecific uptake in the major organs, and photothermal effect upon laser irradiation, making it optimal for bone targeted theranostic imaging.

#NIR imaging #Targeted fluorophore #Structure-inherent targeting #Bone targeting #Renal clearance

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Haoran Wang

소속기관 Department of Pharmacology School of Pharmacy Nanjing University of Chinese Medicine

주요연구분야 공학 > 기타공학 > 의공학

논문수 3 이용수 2

강호만

소속기관 Harvard Medical School

주요연구분야 공학 > 기타공학 > 의공학

논문수 1 이용수 0

Jason Dinh