지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 244 - 252 (9page)
- DOI
- 10.3341/kjo.2021.0041
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초록· 키워드
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Purpose: To investigate the role of serum uric acid and leukocyte counts and ratios as predictors of clinical outcomes of intravitrealbevacizumab in diabetic macular edema.Methods: In this prospective study, the patients were treated with three monthly intravitreal bevacizumab. The correlationof serum uric acid and immune cell indices with the changes of best-corrected visual acuity and central macular thickness atthe end of month 3 were evaluated through univariate and multivariate linear regression analysis.Results: A total of 80 eyes from 80 diabetic patients were included in the study. The difference of uric acid level and immuneindices between groups with different retinopathy severity was not statistically significant (p > 0.05). Lower durationof diabetes (p = 0.045), monocyte count (p = 0.021), and uric acid level (p < 0.001) were correlated with larger improvementin visual acuity at 3-month visit. Higher logarithm of the minimum angle of resolution of baseline visual acuity (p = 0.007),lymphocyte count (p = 0.008), lymphocyte to neutrophil ratio (p < 0.001) and lymphocyte to platelet ratio (p < 0.001) werecorrelated with larger improvement in visual acuity at 3-month visits. According to multivariate analysis, baseline logarithm ofthe minimum angle of resolution (r = 0.125, p = 0.009), duration of diabetes (r = -0.216, p = 0.047), lymphocyte to neutrophilratio (r = 0.712, p < 0.001), lymphocyte to platelet ratio (r = 0.238, p < 0.001), and uric acid level (r = -0.397, p < 0.001) werethe significant predictors of changes in visual acuity in our subset of patients.Conclusions: Serum uric acid and leukocyte counts and ratios may predict the response of diabetic macular edema to intravitrealinjection.
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