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논문 기본 정보

자료유형
학술저널
저자정보
Kwak Seyul (Department of Psychology Pusan National University Busan Korea.) Shin Seong A (Department of Biomedical Sciences Seoul National University Seoul Korea.Department of Nuclear Medic) Ko Hyunwoong (Department of Psychiatry Seoul Metropolitan Government-Seoul National University Boramae Medical Ce) Kim Hairin (Department of Psychiatry Seoul Metropolitan Government-Seoul National University Boramae Medical Ce) Oh Dae Jong (Department of Psychiatry Seoul Metropolitan Government-Seoul National University Boramae Medical Ce) Youn Jung Hae (Department of Art Therapy) Lee Jun-Young (Department of Psychology Pusan National University Busan Korea.) Kim Yu Kyeong (Department of Nuclear Medicine Seoul Metropolitan Government-Seoul National University Boramae Medi)
저널정보
대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제21권 제1호
발행연도
2022.1
수록면
17 - 29 (13page)
DOI
10.12779/dnd.2022.21.1.17

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Background and Purpose: Verbal and nonverbal fluency tests are the conventional methods for examining executive function in the elderly population. However, differences in impairments result in fluency tests in patients with mild cognitive impairments (MCIs) and Alzheimer’s disease (AD) and in neural correlates underlying the tests still necessitate concrete evidence. Methods: We compared the test performances in 27 normal controls, 28 patients with MCI, and 20 with AD, and investigated morphological changes in association with the test performances using structural magnetic imaging. Results: Patients with AD performed poorly across all the fluency tests, and a receiver operating characteristics curve analysis revealed that only category fluency test discriminated all the 3 groups. Association, category, and design fluency tests involved temporal and frontal regions, while letter fluency involved the cerebellum and caudate. Conclusions: Category fluency is a reliable measure for screening patients with AD and MCI, and this efficacy might be related to morphological correlates that underlie semantic and executive processing.

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