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논문 기본 정보

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저자정보
Roh Hyun Woong (Department of Psychiatry Ajou University School of Medicine) Kim Na-Rae (Department of Psychiatry Ajou University School of Medicine) Dong-gi Lee (Department of Psychiatry Ajou University School of Medicine) Cheong Jae-Youn (Department of Gastroenterology Ajou University School of Medicine) Seo Sang Won (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine) Choi Seong Hye (Department of Neurology Inha University School of Medicine) Kim Eun-Joo (Department of Neurology Pusan National University Hospital Pusan National University School of Medi) Cho Soo Hyun (Department of Neurology Chonnam National University Medical School Chonnam National University Hosp) Kim Byeong C. (Department of Neurology Chonnam National University Medical School Chonnam National University Hosp) Kim Seong Yoon (Department of Psychiatry Asan Medical Center University of Ulsan College of Medicine) Kim Eun Young (Department of Brain Science Ajou University School of Medicine) Chang Jaerak (Department of Brain Science Ajou University School of Medicine) Lee Sang Yoon (Department of Biomedical Sciences Ajou University Graduate School of Medicine) Yoon Dukyong (Department of Biomedical Systems Informatics Yonsei University College of Medicine) Choi Jin Wook (Department of Radiology Ajou University School of Medicine) An Young-Sil (Department of Nuclear Medicine and Molecular Imaging Ajou University School of Medicine) Kang Hee Young (Department of Dermatology Ajou University School of Medicine) Shin Hyunjung (Department of Industrial Engineering Ajou University) Park Bumhee (Department of Biomedical Informatics Ajou University School of Medicine) Son Sang Joon (Department of Psychiatry Ajou University School of Medicine) Hong Chang Hyung (Department of Psychiatry Ajou University School of Medicine)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제19권 제2호
발행연도
2022.2
수록면
100 - 109 (10page)
DOI
10.30773/pi.2021.0335

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Objective We aimed to present the study design and baseline cross-sectional participant characteristics of biobank innovations for chronic cerebrovascular disease with Alzheimer’s disease study (BICWALZS) participants.Methods A total of 1,013 participants were enrolled in BICWALZS from October 2016 to December 2020. All participants underwent clinical assessments, basic blood tests, and standardized neuropsychological tests (n=1,013). We performed brain magnetic resonance imaging (MRI, n=817), brain amyloid positron emission tomography (PET, n=713), single nucleotide polymorphism microarray chip (K-Chip, n=949), locomotor activity assessment (actigraphy, n=200), and patient-derived dermal fibroblast sampling (n=175) on a subset of participants.Results The mean age was 72.8 years, and 658 (65.0%) were females. Based on clinical assessments, total of 168, 534, 211, 80, and 20 had subjective cognitive decline, mild cognitive impairment (MCI), Alzheimer’s dementia, vascular dementia, and other types of dementia or not otherwise specified, respectively. Based on neuroimaging biomarkers and cognition, 199, 159, 78, and 204 were cognitively normal (CN), Alzheimer’s disease (AD)-related cognitive impairment, vascular cognitive impairment, and not otherwise specified due to mixed pathology (NOS). Each group exhibited many differences in various clinical, neuropsychological, and neuroimaging results at baseline. Baseline characteristics of BICWALZS participants in the MCI, AD, and vascular dementia groups were generally acceptable and consistent with 26 worldwide dementia cohorts and another independent AD cohort in Korea.Conclusion The BICWALZS is a prospective and longitudinal study assessing various clinical and biomarker characteristics in older adults with cognitive complaints. Details of the recruitment process, methodology, and baseline assessment results are described in this paper.
#Alzheimer's disease #Vascular dementia #Subcortical vascular cognitive impairment #Mild cognitive impairment #Dementia #Cohort.

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