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논문 기본 정보

자료유형
학술저널
저자정보
Yang Chaeyeon (Clinical Emotion and Cognition Research Laboratory Inje University Goyang Republic of Korea) Kwon Aeran (Department of Social Welfare and Counseling Chodang University Muan Republic of Korea) Jung Bori (Clinical Emotion and Cognition Research Laboratory Inje University Goyang Republic of Korea) Lee Hyun Seo (College of Arts and Science New York University New York NY USA) Kim Hyang Sook (Department of Psychology Sogang University Seoul Republic of Korea) Lee Seung-Hwan (Clinical Emotion and Cognition Research Laboratory Inje University Goyang Republic of Korea)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제19권 제10호
발행연도
2022.10
수록면
857 - 865 (9page)
DOI
10.30773/pi.2022.0189

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Objective This study aimed to explore the relationship between childhood physical abuse and suicidal ideation considering the effects of genetic and environmental factors in patients with post-traumatic stress disorder (PTSD) by focusing on brain-derived neurotrophic factor (BDNF) polymorphism and social support, respectively.Methods One-hundred fourteen patients with PTSD and 94 healthy controls (HCs) were genotyped with respect to BDNF Val66Met polymorphism. All participants underwent psychological assessments. The hierarchical regression analysis and the simple slope analysis were conducted.Results As for patients with PTSD, the moderation effect of BDNF polymorphism was significant but not for social support. Specifically, the BDNF Val/Val genotype worked as a risk factor and strengthens the relationship between childhood physical abuse and suicidal ideation. As for the HCs, the significant moderation effect was found only in social support, but not for BDNF polymorphism. The relationship between childhood physical abuse and suicidal ideation was weakened for the HCs with high social support.Conclusion This study demonstrated a significant BDNF genetic vulnerability for suicide in patients with PTSD who experienced childhood physical abuse. Our results suggested that social support provided a mitigating effect on the relationship between childhood physical abuse and suicidal ideation only in the HCs.

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