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논문 기본 정보

자료유형
학술저널
저자정보
Shih-Ku Lin (Psychiatric Center Taipei City Hospital) Shu-Yu Yang (Deparment of Pharmacy Songde Branch Tapei City Hospital) Seon-Cheol Park (Hanyang University) Ok-Jin Jang (Department of Psychiatry Bugok National Hospital) Xiaomin Zhu (Suzhou Guangji Hospital) Yu-Tao Xiang (Unit of Psychiatry Department of Public Health and Medicinal Administration University of Macau) Wen-Chen Ouyang (Jianan Psychiatric Center) Afzal Javed (Pakistan Psychiatric Research Centre Fountain House) M. Nasar Sayeed Khan (Services Hospital) Sandeep Grover (Post Graduate Institute of Medical Education and Research) Ajit Avasthi (Department of Psychiatry Post Graduate Institute of Medical Education and Research) Roy Abraham Kallivayalil (Department of Psychiatry Pushpagiri Institute of Medical Sciences) Kok Yoon Chee (Kuala Lumpur Hospital) Norliza Chemi (Hospital Kajang) Takahiro A. Kato (Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University) Kohei Hayakawa (Kyushu University) Pornjira Pariwatcharakul (Mahidol University) Margarita Maramis (Airlangga University) Lakmi Seneviratne (University of Sri Jayewardenepura) Sim Kang (Buangkok Green Medical Park) Wai Kwong Tang (Department of Psychiatry Chinese University of Hong Kong Hong Kong China) Tin Oo (Yangon University of Medicine) Norman Sartorius (Association for the Improvement of Mental Health Programs) Chay Hoon Tan (National University of Singapore) Mian-Yoon Chong (Kaohsiung & Chang Gung University School of Medicine) Yong Chon Park (Department of Neuropsychiatry Hanyang University Guri Hospital) Naotaka Shinfuku (Department of Social Welfare School of Human Sciences Seinan Gakuin University)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제20권 제1호
발행연도
2022.2
수록면
61 - 69 (9page)
DOI
10.9758/cpn.2022.20.1.61

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Objective: Pharmacotherapy including mood stabilizers and antipsychotics are frequently used in bipolar disorder (BD); however, the lack of consensus regarding the definition of polypharmacy hinders conducting comparative studies across different settings and countries. Research on Asian Prescription Pattern (REAP) is the largest and the longest lasting international collaborative research in psychiatry in Asia. The objective of REAP BD was to investigate the prescription patterns of psychotropic medications across Asian countries. The rates of polypharmacy and psychotropic drug load were also analyzed. Methods: The data collection was web-based. Prescription patterns were categorized as (1) mood stabilizer monotherapy: one mood stabilizer; (2) antipsychotic monotherapy: one antipsychotic; (3) simple polypharmacy: one mood stabilizer and one antipsychotic; and (4) complex polypharmacy: ≥ 2 mood stabilizers or/and antipsychotics. The psychotropic drug load in each patient was calculated using the defined daily dose method. Results: Among 2003 patients with BD (52.1% female, 42.4 years) from 12 countries, 1,619 (80.8%) patients received mood stabilizers, 1,644 (82.14%) received antipsychotics, and 424 (21.2%) received antidepressants, with 14.7% mood stabilizer monotherapy, 13.4% antipsychotic monotherapy, 48.9% simple polypharmacy, 20.3% complex polypharmacy, and 2.6% other therapy. The average psychotropic drug load was 2.05 ± 1.40. Results varied widely between countries. Conclusion: Over 70% of psychotropic regimens involved polypharmacy, which accords with the high prevalence of polypharmacy in BD under a permissive criterion (2 or more core psychotropic drugs) worldwide. Notably, ≥ 80% of our sample received antipsychotics, which may indicate an increasing trend in antipsychotic use for BD treatment.
#Bipolar disorder #Polypharmacy #Psychotropic drug load #Antipsychotics #Mood stabilizers.

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