Serotonin Modulates the Correlations between Obsessive-compulsive Trait and Heart Rate Variability in Normal Healthy Subjects: A SPECT Study with [ 123 I]ADAM and Heart Rate Variability Measurement

Che Yu Kuo; Kao Chin Chen; I Hui Lee; Huai-Hsuan Tseng; Nan-Tsing Chiu; Po See Chen; Yen Kuang Yang; Wei Hung Chang

doi:10.9758/cpn.2022.20.2.271

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자료유형: 학술저널

저자정보: Che Yu Kuo (National Cheng Kung University) Kao Chin Chen (National Cheng Kung University) I Hui Lee (National Cheng Kung University) Huai-Hsuan Tseng (National Cheng Kung University) Nan-Tsing Chiu (National Cheng Kung University) Po See Chen (National Cheng Kung University) Yen Kuang Yang (National Cheng Kung University) Wei Hung Chang (National Cheng Kung University)

저널정보: 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제20권 제2호

발행연도: 2022.5

수록면: 271 - 278 (8page)

DOI: 10.9758/cpn.2022.20.2.271

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Objective: The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain. Methods: We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [123I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium. Results: The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability. Conclusion: OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.

#Autonomic nervous system #Heart rate variability #Obsessive compulsive symptoms #Serotonin transporter availability.

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