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논문 기본 정보

자료유형
학술저널
저자정보
Ji Won Kim (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Tae Jun Kim (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Ji Eun Kim (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Ji Eun Na (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Hyuk Lee (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Byung-Hoon Min (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Jun Haeng Lee (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Poong-Lyul Rhee (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine) Jae J Kim (Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.22 No.2
발행연도
2022.6
수록면
131 - 138 (8page)

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Background/Aims: Previous studies have reported an association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD). Our study examined whether eradication for H. pylori infection reduces the risk of incident NAFLD. Materials and Methods: This retrospective cohort study examined 3,780 adults who had no NAFLD at baseline but were infected with H. pylori. The study population was followed from January 1995 until January 2020. H. pylori infection was determined by an H. pylori-specific IgG antibody test. Fatty liver was diagnosed by ultrasound. Results: During a median follow-up of 7.9 years, 1,294 participants developed NAFLD. In a multivariable model adjusted for age, sex, BMI, smoking status, alcohol intake, and metabolic variables, the uneradicated (for H. pylori) group exhibited a higher risk of incident NAFLD than the eradicated group (hazard ratio [HR], 1.36; 95% CI, 1.18~1.56). The multivariable analysis also demonstrated that higher BMI, current smoking and several metabolic abnormalities were significant risk factors for NAFLD. Subgroup analyses revealed that persistent H. pylori infection correlated with an increased risk of NAFLD. H. pylori eradication was associated with a decreased risk of NAFLD development. Conclusions: H. pylori infection may have a pathophysiological role in NAFLD development. Hence, successful eradication of H. pylori decreases the risk of incident NAFLD.

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