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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 13 - 26 (14page)
- DOI
- 10.1007/s13206-021-00043-y
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초록· 키워드
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Microphysiological systems are in vitro tissue and organ models that present unique opportunities across different disciplines, such as biology, medicine, and engineering. These systems are preferred over two-dimensional simplistic cell cultures and animal models with poor translatability. Microphysiological systems can facilitate the understanding of human physiology and pathophysiology by recapitulating specific organ structures and functions. Recent advances in microphysiological systems employ microfluidic technologies to gain deeper insights into more complex in vivo physiological phenomena and mechanisms. More specifically, microfluidic technologies allow the development of more realistic physiological conditions.
This review highlights recent advances in microfluidic-based microphysiological systems and comprehensively discusses the relationship between the design and operation of microfluidic systems for mimicking physiological microenvironments.
Moreover, several representative examples and their potential biological applications are described and explained in detail.
Finally, the review concludes with current perspectives, limitations, and prospects for further improving the microfluidicbased microphysiological systems.
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