Effects of Preoperative Acupuncture on Prevention of Nausea and Vomiting and Plasma Serotonin Values in the Hysterectomy Postoperative Period: a Randomized Clinical Trial

Pires Michelle Catarina; Barros Guilherme Antonio Moreira de; Fonseca Lucas Guimarães Ferreira; Thom Murilo Moreira; Junior Paulo do Nascimento; Módolo Norma Sueli Pinheiro

doi:10.51507/j.jams.2022.15.5.300

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자료유형: 학술저널

저자정보: Pires Michelle Catarina (Department of Surgical Specialties and Anaesthesiology Botucatu Medical School São Paulo State Univ) Barros Guilherme Antonio Moreira de (Department of Surgical Specialties and Anaesthesiology Botucatu Medical School São Paulo State Univ) Fonseca Lucas Guimarães Ferreira (Department of Surgical Specialties and Anaesthesiology Botucatu Medical School São Paulo State Univ) Thom Murilo Moreira (Department of Surgical Specialties and Anaesthesiology Botucatu Medical School São Paulo State Univ) Junior Paulo do Nascimento (Department of Surgical Specialties and Anaesthesiology Botucatu Medical School São Paulo State Univ) Módolo Norma Sueli Pinheiro (Department of Surgical Specialties and Anaesthesiology Botucatu Medical School São Paulo State Univ)

저널정보: 대한약침학회 Journal of Acupuncture & Meridian Studies Journal of Acupuncture & Meridian Studies Vol.15 No.5

발행연도: 2022.11

수록면: 300 - 306 (7page)

DOI: 10.51507/j.jams.2022.15.5.300

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Background: Nausea and vomiting are frequent complications of anesthesia in the postoperative period. Acupuncture at the pericardium point 6 (PC6) is known to be effective in preventing postoperative nausea and vomiting (PONV). Objectives: The objective of the present study is to investigate the effects of acupuncture performed at the PC6 point in the prevention of PONV in women undergoing elective open hysterectomy under general inhalational anesthesia and to assess its association with plasma serotonin levels. Methods: 97 patients undergoing elective open hysterectomy were randomly divided into two groups: acupuncture group (bilateral acupuncture at PC6, n = 49), and a control group (no acupuncture, n = 48). All patients prophylactically received ondansetron and dexamethasone and, as rescue medication, metoclopramide in case of occurrence of PONV. The primary outcome evaluated was occurrence of nausea and vomiting within 24 hours after surgery. Serotonin plasma levels were measured before and after acupuncture prior to anesthesia induction. For the control group, the repeat measurement was performed 30 minutes after admission to the preoperative unit. Results: Acupuncture at PC6 significantly reduced the incidence of nausea (29.2% vs. 6.1%; p < 0.003), and the need of rescue medication (metoclopramide) (33.3% vs. 10.2%; p < 0.006), but not vomiting (4.2 vs. 4.1; p < 0.98). The plasma serotonin levels between control and acupuncture groups did not differ. Conclusion: This study shows that acupuncture at PC6 resulted in a lower incidence of postoperative nausea in patients undergoing hysterectomy.

#Acupuncture therapy #Acupuncture points #Postoperative nausea and vomiting #Serotonin

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