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논문 기본 정보

자료유형
학술저널
저자정보
Cho Hyo Jung (Department of Gastroenterology Ajou University School of Medicine Suwon Korea) Ahn Young Hwan (Department of Gastroenterology Ajou University School of Medicine Suwon Korea) Sim Min Suh (Department of Gastroenterology Ajou University School of Medicine Suwon Korea) Eun Jung Woo (Department of Gastroenterology Ajou University School of Medicine Suwon Korea) Kim Soon Sun (Department of Gastroenterology Ajou University School of Medicine Suwon Korea) Kim Bong Wan (Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of Medicine Su) Huh Jimi (Department of Radiology Ajou University School of Medicine Suwon Korea) Lee Jei Hee (Department of Radiology Ajou University School of Medicine Suwon Korea) Kim Jai Keun (Department of Radiology Ajou University School of Medicine Suwon Korea) Lee Buil (Insight Mining Corporation Daejeon Korea) Cheong Jae Youn (Department of Radiology Ajou University School of Medicine Suwon Korea) Kim Bohyun (Department of Radiology Ajou University School of Medicine Suwon KoreaDepartment of Radiology Seoul)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제16권 제2호
발행연도
2022.3
수록면
277 - 289 (13page)
DOI
10.5009/gnl210130

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Background/Aims: Posthepatectomy liver failure (PHLF) is a major complication that increases mortality in patients with hepatocellular carcinoma after surgical resection. The aim of this retrospective study was to evaluate the utility of magnetic resonance elastography-assessed liver stiffness (MRE-LS) for the prediction of PHLF and to develop an MRE-LS-based risk prediction model. Methods: A total of 160 hepatocellular carcinoma patients who underwent surgical resection with available preoperative MRE-LS data were enrolled. Clinical and laboratory parameters were collected from medical records. Logistic regression analyses were conducted to identify the risk factors for PHLF and develop a risk prediction model. Results: PHLF was present in 24 patients (15%). In the multivariate logistic analysis, high MRE-LS (kPa; odds ratio [OR] 1.49, 95% confidence interval [CI] 1.12 to 1.98, p=0.006), low serum albumin (≤3.8 g/dL; OR 15.89, 95% CI 2.41 to 104.82, p=0.004), major hepatic resection (OR 4.16, 95% CI 1.40 to 12.38, p=0.014), higher albumin-bilirubin score (>?0.55; OR 3.72, 95% CI 1.15 to 12.04, p=0.028), and higher serum α-fetoprotein (>100 ng/mL; OR 3.53, 95% CI 1.20 to 10.40, p=0.022) were identified as independent risk factors for PHLF. A risk prediction model for PHLF was established using the multivariate logistic regression equation. The area under the receiver operating characteristic curve (AUC) of the risk prediction model was 0.877 for predicting PHLF and 0.923 for predicting grade B and C PHLF. In leave-one-out cross-validation, the risk model showed good performance, with AUCs of 0.807 for all-grade PHLF and 0. 871 for grade B and C PHLF. Conclusions: Our novel MRE-LS-based risk model had excellent performance in predicting PHLF, especially grade B and C PHLF.

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