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논문 기본 정보

자료유형
학술저널
저자정보
Hye-Kyung Jung (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea) Chung Hyun Tae (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea;) Hye Ah Lee (Clinical Trial Center Mokdong Hospital Ewha Womans University Seoul Korea) Ko Eun Lee (Department of Internal Medicine Ewha Womans University Seoul Korea) Chang Mo Moon (Department of Internal Medicine Ewha Womans University Seoul Korea) Seong Eun Kim (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea) Ju Young Seoh (Department of Microbiology Ewha Womans University Seoul Korea) Joo-Ho Lee (Department of Surgery Ewha Womans University Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.3
발행연도
2022.7
수록면
409 - 417 (9page)
DOI
10.5056/jnm21145

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Background/AimsPost-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. MethodsThis prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. ResultsThe mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (ρ = ?0.8, P = 0.024). ConclusionsSignificant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.

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