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논문 기본 정보

자료유형
학술저널
저자정보
Ju Hee Kim (Department of Pediatrics Hallym University Kangdong Sacred Heart Hospital Seoul Korea) Seung Won Lee (Department of Precision Medicine Sungkyunkwan University School of Medicine Suwon Gyeonggi-do Korea) Yoowon Kwon (Department of Pediatrics Chungnam National University Sejong Hospital Sejong Korea) Eun Kyo Ha (Department of Pediatrics Hallym University Kangnam Sacred Heart Hospital Seoul Korea) Jaewoo An (Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine Seongnam Gyeo) Hye Ryeong Cha (Department of Comuputer Science and Engineering Sungkyunkwan University Suwon Gyeonggi-do Korea) Su Jin Jeong (Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine Seongnam Gyeo) Man Yong Han (Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine Seongnam Gyeo)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.4
발행연도
2022.10
수록면
618 - 629 (12page)
DOI
10.5056/jnm21181

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"Background/Aims Little is known about the association between infantile colic and the later onset of irritable bowel syndrome (IBS). Methods This study examined all 917 707 children who were born in Korea between 2007 and 2008. Infantile colic was defined with 1 or more diagnoses of ICD-10 code R10.4 or R68.1 at the age of 5 weeks to 4 months, and infants with a diagnosis of infantile colic and without were allocated into the infantile colic group and the control group. IBS was defined as 2 or more diagnoses of ICD-10 code K58.X after 4 years of age. Each child was traced until 2017. The risk of IBS with infantile colic was evaluated using a Cox proportional hazards model with propensity score inverse probability of treatment weighting (IPTW). Results After IPTW, 363 528 and 359 842 children were allocated to the control group and the infantile colic group, respectively. The infantile colic group had a higher risk of developing IBS in childhood (hazard ratio [95% CI], 1.12 [1.10 to 1.13]) than the control group. Moreover, the subgroup analyses according to the feeding status, birth weight, sex, or economic status, showed that the risk of IBS with former infantile colic remained statistically significant. Conclusions Children with a diagnosis of infantile colic during the infant period had a significant risk of developing IBS after 4 years of age. Understanding the pathogenesis of infantile colic in the neonatal period may reduce the prevalence and severity of functional gastrointestinal disorders from childhood to adolescence to adulthood"

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