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논문 기본 정보

자료유형
학술저널
저자정보
Kwon Jae-Woo (Division of Allergy and Clinical Immunology Department of Internal Medicine Kangwon National Univer) Kim Mi-Ae (Department of Pulmonology Allergy and Critical Care Medicine CHA Bundang Medical Center CHA Univers) Sim Da Woon (Division of Allergy Asthma and Clinical Immunology Department of Internal Medicine Chonnam National) Lee Hwa Young (Division of Allergy Department of Internal Medicine College of Medicine Seoul St. Mary’s Hospital T) Rhee Chin Kook (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine College of Medicin) Yang Min-Suk (Department of Internal Medicine Seoul Metropolitan Government - Seoul National University Boramae M) 심지수 (Department of Internal Medicine Ewha Womans University College of Medicine Seoul Korea.) 김민혜 (Department of Internal Medicine Ewha Womans University College of Medicine Seoul Korea.) Kim So Ri (Division of Respiratory Medicine and Allergy Department of Internal Medicine Jeonbuk National Unive) Park Chan Sun (Department of Internal Medicine Inje University Haeundae Paik Hospital Inje University College of M) Kim Byung-Keun (Division of Pulmonology Allergy and Critical Care Medicine Department of Internal Medicine Korea Un) Kang Sung-Yoon (Department of Internal Medicine Gachon University Gil Medical Center Incheon Korea.) Choi Gil-Soon (Department of Internal Medicine Kosin University College of Medicine Busan Korea.) Lee Hyun (Department of Internal Medicine Hanyang University College of Medicine Seoul Korea.) Jang An-Soo (Department of Internal Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) 김상헌 (Department of Internal Medicine Hanyang University College of Medicine Seoul Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.14 No.3
발행연도
2022.5
수록면
300 - 313 (14page)
DOI
10.4168/aair.2022.14.3.300

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Purpose: Oral corticosteroids (OCSs) are frequently prescribed for asthma management despite their adverse effects. An understanding of the pattern of OCS treatment is required to optimize asthma treatment and reduce OCS usage. This study evaluated the prescription patterns of OCSs in patients with asthma. Methods: This is a retrospective multicenter observational study. We enrolled adult (≥18 years) patients with asthma who had been followed up by asthma specialists in 13 university hospitals for ≥3 years. Lung function tests, the number of asthma exacerbations, and prescription data, including the days of supply and OCS dosage, were collected. The clinical characteristics of OCS-dependent and exacerbation-prone asthmatic patients were evaluated. Results: Of the 2,386 enrolled patients with asthma, 27.7% (n = 660) were OCS users (the median daily dose of OCS was 20 mg/day prednisolone equivalent to a median of 14 days/year). OCS users were more likely to be female, to be treated at higher asthma treatment steps, and to show poorer lung function and more frequent exacerbations in the previous year than non-OCS users. A total of 88.0% of OCS users were treated with OCS burst with a mean dose of 21.6 ± 10.2 mg per day prednisolone equivalent to 7.8 ± 3.2 days per event and 2.4 times per year. There were 2.1% (51/2,386) of patients with OCS-dependent asthma and 9.5% (227/2,386) with exacerbation-prone asthma. These asthma phenotypes were consistent over the 3 consecutive years in 47.1% of OCS-dependent asthmatic patients and 34.4% of exacerbation-prone asthmatic patients when assessed annually over the 3-year study period. Conclusions: We used real-world data from university hospitals in Korea to describe the OCS prescription patterns and relievers in asthma. Novel strategies are required to reduce the burden of OCS use in patients with asthma.
#Asthma #corticosteroid #phenotype #disease exacerbation #prescription patterns #lung function tests

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