지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 38 - 48 (11page)
- DOI
- 10.4093/dmj.2021.0045
이용수
초록· 키워드
오류제보하기
The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian people whose capacity for insulin secretion is inherently lower than that of other ethnic populations. Causally, changes of environmental factors in addition to intrinsic genetic factors have been considered to have an influence on the increased prevalence of diabetes. Particular focus has been placed on “gene-environment interactions” in the development of a reduced pancreatic β-cell mass, as well as type 1 and type 2 diabetes mellitus. Changes in the intrauterine environment, such as intrauterine growth restriction, contribute to alterations of gene expression in pancreatic β-cells, ultimately resulting in the development of pancreatic β-cell failure and diabetes. As a molecular mechanism underlying the effect of the intrauterine environment, epigenetic modifications have been widely investigated. The association of diabetes susceptibility genes or dietary habits with gene-environment interactions has been reported. In this review, we provide an overview of the role of gene-environment interactions in pancreatic β-cell failure as revealed by previous reports and data from experiments.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pathophysiology of Type 2 Diabetes in Koreans
Endocrinology and Metabolism
2018 .01
-
Pancreatic tuberculosis revealed by a pancreatic mass
대한외과학회 학술대회 초록집
2017 .11
-
Assessment of Insulin Secretion and Insulin Resistance in Human
Diabetes and Metabolism Journal
2021 .09
-
Gender differences on pancreatic beta cell dysfunction and insulin secretion in type 2 diabetic ICR mice
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Pancreatic Cancer
대한외과학회 학술대회 초록집
2021 .11
-
Regulating long-term blood glucose level of type 1 diabetes mouse by transplantation of hydrogel nanofilm encapsulated pancreatic β-cell spheroids
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis
The Korean Journal of Physiology & Pharmacology
2024 .01
-
20대 젊은 남자에서 발병한 췌장암
대한내과학회지
2020 .02
-
Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential
생체재료학회지
2023 .03
-
History of insulin treatment of pediatric patients with diabetes in Korea
Annals of Pediatirc Endocrinology & Metabolism
2021 .12
-
Pancreatic metastases mimicking primary pancreatic cancer : A case report
한국간담췌외과학회 학술대회지
2016 .04
-
급성췌장염으로 첫 임상 발현한 1A 병기 췌장암
대한내과학회지
2019 .12
-
A Case of Five-Year Survival in Metastatic Pancreatic Cancer
대한췌담도학회지
2024 .07
-
Incretin and Pancreatic β-Cell Function in Patients with Type 2 Diabetes
Endocrinology and Metabolism
2023 .02
-
Identification of sphingosine 1-phosphate level and MAPK/ERK signaling in pancreatic β cells
Annals of Pediatirc Endocrinology & Metabolism
2021 .12
-
Public Fear of Pancreatic Diseases: Causes and Clinical Outcomes at a Single Korean Center
Gut and Liver
2024 .07
-
췌장암 조기진단을 위한 조건부 확률 기반 지능형 진단 방식
의공학회지
2017 .01
-
Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
Diabetes and Metabolism Journal
2022 .07
-
Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index
Diabetes and Metabolism Journal
2018 .01
-
Effect of Psychological Insulin Resistance, Diabetes Distress, and Diabetes Self-Efficacy on the Insulin Therapy Adherence of Patients with Type 2 Diabetes: An Analysis Based on the Actor-Partner Interdependence Model
성인간호학회지
2020 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0